原创力文档construct validity of a continuous metabolic syndrome score in children建构效度的连续代谢综合症儿童的得分.pdfVIP
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construct validity of a continuous metabolic syndrome score in children建构效度的连续代谢综合症儿童的得分
Eisenmann et al. Diabetology Metabolic Syndrome 2010, 2:8
DIABETOLOGY
/content/2/1/8
METABOLIC SYNDROME
RESEARCH Open Access
Construct validity of a continuous metabolic
syndrome score in children
1* 2 3 4 4
Joey C Eisenmann , Kelly R Laurson , Katrina D DuBose , Bryan K Smith , Joseph E Donnelly
Abstract
Objective: The primary purpose of this study was to examine the construct validity of a continuous metabolic
syndrome score (cMetS) in children. The secondary purpose was to identify a cutpoint value(s) for an adverse
cMetS based on receiver operating characteristic (ROC) curve analysis.
Methods: 378 children aged 7 to 9 years were assessed for the metabolic syndrome which was determined by
age-modified cutpoints. High-density-lipoprotein cholesterol, triglycerides, the homeostasis assessment model of
insulin resistance, mean arterial pressure, and waist circumference were used to create a cMetS for each subject.
Results: About half of the subjects did not possess any risk factors while about 5% possessed the metabolic
syndrome. There was a graded relationship between the cMetS and the number of adverse risk factors. The cMetS
was lowest in the group with no adverse risk factors (-1.59 ± 1.76) and highest in those possessing the metabolic
syndrome (≥3 risk factors) (7.05 ± 2.73). The cutoff level yielding the maximal sensitivity and specificity for
predicting the presence of the metabolic syndrome was a cMetS of 3.72 (sensitivity = 100%, specificity = 93.9%,
and the area of the curve = 0.97
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