尼美舒利对脑膜瘤细胞ETS-1及MMP-1表达和对脑膜瘤细胞增殖及凋亡影响.pdf

尼美舒利对脑膜瘤细胞ETS-1及MMP-1表达和对脑膜瘤细胞增殖及凋亡影响.pdf

ABSTI认CT Objective: fromthe arethetumorsthatarise arachnoid Meningiomas,which cap 13—25%ofalltumorsofthecentral cells,compriseapproximately nervous Clinicalevidence the that conceptmeningioma system supports formationbeassociatedwith headtrauma.Theevidence may previous formationoccurinthe ofchronic that setting suggestsmeningioma may inflan呲nation trauma.Cox一2isthe in by rate—limitingenzyme triggered from acid. the of arachidonic synthesisprosta91andins Prosta91andins have and antiapoptoticproperties.The angiogenic,cell—proliferatiVe, Ets一1 factor an roleinvarious transcriptionand衄p一1playimportant and extracellularremodel physiologicpathologicprocessesrequiring ing suchastumor and invasion,angiogenesis selective theeffectsof and ontumorcells.Theaimof property antiproliferativeproapoptotic intreatmentofhuman theresearchistofindthe ofNimesulide possibility meansof cell andthe meningiomaby studyingproliferation,ap

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