氯仿对小鼠生殖细胞遗传物质及性激素影响的研究.pdfVIP

中南大学公j《。I!生学院硕士沦文 英文摘要 TheEffectsof ChloroformonGermPlasm ofGermCelland hormoneofMice gonadal ABSTRACT the and [Objective|To materials studygeneraltoxicitygenetic ofcldoroform damage on cellsindifferent hadobserved geml stages，we micewhichwere tochloroform Kunming exposed bypouring．We somekindof investgtaled hormoneinblood gonadal serum，spermic maltbrma!ionandchromosomal aberrationin cells．Wehadobserved germ the structureof hisiopalhological and hypothalamus discoverthe gonad．To mechanismof genetivetoxicity haddetected chloroform，we theestrous andtheGSH cycle levelinthe gonad． [Methods]Male micein Kunming had sitldy：Chloroform grolIPs been tochloroform exposed by for5 doses pouringdays，chloroformwere： 1 2 56mg／kg。bw,1 mg／kg’bw,224 killedsomemiceatthe mg／kg·bw．We sixth wasused day．HE