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什么是夫妻什么是家（What is husband and wife What is home） The research progress of liposome for pulmonary medicine Bi Ru, Shao Wei (Shandong University School of medicine, Jinan 250012) Abstract: This paper introduces the characteristics and methods of liposome for pulmonary medicine, reviewed the related lipid carrier at home and abroad in recent years as antibiotics, antiasthmatic drugs, anticancer drugs, peptides and protein drugs and gene drugs, through the study of pulmonary delivery of local and systemic therapeutic effects, and to evaluate its safety. Keywords: liposome; pulmonary delivery; drug carrier; safety Liposomes for pulmonary medicine has a long history, was first used in the treatment of respiratory distress syndrome. In 1979 McCullough and [1] found that beta cytarabine solution by intratracheal instillation after quickly cleared from the lung, and the mixed liposomes hardly to other tissues and distribution of suspension, and has remained in the bronchial space, so the early research focused on the treatment of pulmonary local disease. Along with the development of gene drugs, pharmaceutical excipients, new devices and new drug development, and liposome itself has the properties of high bioavailability, fewer adverse reactions, sustainable slow drug release, liposome as a carrier of local or systemic drugs for pulmonary drug delivery has been paid more and more attention, the relevant research progress is summarized as follows. 1. characteristics of pulmonary delivery of liposomes Pulmonary drug delivery and other routes of administration, has the following features: convenient administration, mainly by inhalation administration, with strong adaptability. The absorption of a large surface area, the absorption site of rich blood flow, blood drug through the air - way to exchange a short distance, fast speed. The lung is composed of a single layer of epithelial cells, epithelial barrier is thin, high permeability, high delivery of macromolecular drugs. It ca