a combined transcriptomics and lipidomics analysis of subcutaneous, epididymal and mesenteric adipose tissue reveals marked functional differences结合转录组和lipidomics分析皮下,附睾的和肠系膜脂肪组织显示明显的功能差异.pdfVIP

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2017-09-07 发布于上海
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a combined transcriptomics and lipidomics analysis of subcutaneous, epididymal and mesenteric adipose tissue reveals marked functional differences结合转录组和lipidomics分析皮下,附睾的和肠系膜脂肪组织显示明显的功能差异.pdf

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a combined transcriptomics and lipidomics analysis of subcutaneous, epididymal and mesenteric adipose tissue reveals marked functional differences结合转录组和lipidomics分析皮下,附睾的和肠系膜脂肪组织显示明显的功能差异

A Combined Transcriptomics and Lipidomics Analysis of Subcutaneous, Epididymal and Mesenteric Adipose Tissue Reveals Marked Functional Differences 1,2 3 4 5,6 4 Robert Caesar *, Monia Manieri , Thomas Kelder , Mark Boekschoten , Chris Evelo , Michael ¨ 5,6 7 3 7 1 Muller , Teake Kooistra , Saverio Cinti , Robert Kleemann , Christian A. Drevon 1 Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway, 2 Wallenberg Laboratory/Sahlgrenska Center for Cardiovascular and Metabolic Research, University of Gothenburg, Gothenburg, Sweden, 3 Department of Molecular Pathology and Innovative Therapies, School of Medicine, University of Ancona, Ancona, Italy, 4 Department of Bioinformatics, BiGCaT, Maastricht University, Maastricht, The Netherlands, 5 Nutrigenomics Consortium, TI Food Nutrition, Wageningen, The Netherlands, 6 Nutrition, Metabolism and Genomics Group, Division of Human Nutrition, Wageningen University, Wageningen, The Netherlands, 7 BioSciences, TNO-Quality of Life, Leiden, The Netherlands Abstract Depot-dependent differences in adipose tissue physiology may reflect specialized functions and local interactions between adipocytes and surrounding tissues. We combined time-resolved microarray analyses of mesenteric- (MWAT), subcutaneous- (SWAT) and epididymal adipose tissue (EWAT) during high-fat feeding of male transgenic ApoE3Leiden mice with histology, targeted lipidomics and biochemical analyses of metabolic pathways to identify differentially regulated processes and s