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a computational tool for quantitative analysis of vascular networks血管网络的定量分析的计算工具
A Computational Tool for Quantitative Analysis of
Vascular Networks
1 2 3 2
Enrique Zudaire *, Laure Gambardella , Christopher Kurcz , Sonja Vermeren *
1 Angiogenesis Core Facility, Radiation Oncology Branch, National Institute of Health National Cancer Institute, Gaithersburg, Maryland, United States of America,
2 Inositide Laboratory, The Babraham Institute, Babraham Research Campus, Cambridge, United Kingdom, 3 Advanced Biomedical Computing Center - Information
System Program, Science Applications International Corporation-Frederick Inc, Frederick, Maryland, United States of America
Abstract
Angiogenesis is the generation of mature vascular networks from pre-existing vessels. Angiogenesis is crucial during the
organism’ development, for wound healing and for the female reproductive cycle. Several murine experimental systems are
well suited for studying developmental and pathological angiogenesis. They include the embryonic hindbrain, the post-
natal retina and allantois explants. In these systems vascular networks are visualised by appropriate staining procedures
followed by microscopical analysis. Nevertheless, quantitative assessment of angiogenesis is hampered by the lack of readily
available, standardized metrics and software analysis tools. Non-automated protocols are being used widely and they are, in
general, time - and labour intensive, prone to human error and do not permit computation of complex spatial metrics. We
have developed a light-weight, user friendly software, AngioTool, which allows for quick, hands-off and reproducible
quantification of vascular networks in microscopic images. AngioTool computes several morphological and spatial
parameters including the area cov
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