a family of helminth molecules that modulate innate cell responses via molecular mimicry of host antimicrobial peptides家庭的寄生虫分子调节固有细胞反应通过主机抗菌肽分子拟态.pdfVIP

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a family of helminth molecules that modulate innate cell responses via molecular mimicry of host antimicrobial peptides家庭的寄生虫分子调节固有细胞反应通过主机抗菌肽分子拟态.pdf

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a family of helminth molecules that modulate innate cell responses via molecular mimicry of host antimicrobial peptides家庭的寄生虫分子调节固有细胞反应通过主机抗菌肽分子拟态

A Family of Helminth Molecules that Modulate Innate Cell Responses via Molecular Mimicry of Host Antimicrobial Peptides 1. 1. 1 1 2 Mark W. Robinson *, Sheila Donnelly , Andrew T. Hutchinson , Joyce To , Nicole L. Taylor , 3 2 4. Raymond S. Norton , Matthew A. Perugini , John P. Dalton 1 Infection, Immunity and Innovation (i3) Institute, University of Technology Sydney (UTS), Ultimo, Sydney, Australia, 2 Department of Biochemistry and Molecular Biology, Bio21 Molecular Science and Biotechnology Institute, University of Melbourne, Australia, 3 Monash Institute of Pharmaceutical Research, Monash University, Parkville, Australia, 4 Institute of Parasitology, McDonald Campus, McGill University, St. Anne de Bellevue, Quebec, Canada Abstract Over the last decade a significant number of studies have highlighted the central role of host antimicrobial (or defence) peptides in modulating the response of innate immune cells to pathogen-associated ligands. In humans, the most widely studied antimicrobial peptide is LL-37, a 37-residue peptide containing an amphipathic helix that is released via proteolytic cleavage of the precursor protein CAP18. Owing to its ability to protect against lethal endotoxaemia and clinically-relevant bacterial infections, LL-37 and its derivatives are seen as attractive candidates for anti-sepsis therapies. We have identified a novel family of molecules secreted by parasitic helminths (helminth defence molecules; HDMs) that exhibit similar biochemical and functional characteristics to human defence peptides, particularly CAP18. The HDM secreted by Fasciola hepatica (FhHDM-1) adopts a pre