a monoclonal antibody-gdnf fusion protein is not neuroprotective and is associated with proliferative pancreatic lesions in parkinsonian monkeys单克隆antibody-gdnf融合蛋白不是神经保护和增殖有关胰腺病变帕金森猴子.pdfVIP

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2017-09-07 发布于上海
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a monoclonal antibody-gdnf fusion protein is not neuroprotective and is associated with proliferative pancreatic lesions in parkinsonian monkeys单克隆antibody-gdnf融合蛋白不是神经保护和增殖有关胰腺病变帕金森猴子.pdf

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a monoclonal antibody-gdnf fusion protein is not neuroprotective and is associated with proliferative pancreatic lesions in parkinsonian monkeys单克隆antibody-gdnf融合蛋白不是神经保护和增殖有关胰腺病变帕金森猴子

A Monoclonal Antibody-GDNF Fusion Protein Is Not Neuroprotective and Is Associated with Proliferative Pancreatic Lesions in Parkinsonian Monkeys 1. 2. 2 1,3 Sachiko Ohshima-Hosoyama , Heather A. Simmons , Nichole Goecks , Valerie Joers , 1,3 1 1 2 5 Christine R. Swanson , Viktoriya Bondarenko , Rebecca Velotta , Kevin Brunner , Laura D. Wood , Ralph H. Hruban5, Marina E. Emborg1,2,3,4* 1 Preclinical Parkinson’s Research Program, Wisconsin National Primate Research Center, University of Wisconsin–Madison, Madison, Wisconsin, United States of America, 2 Wisconsin National Primate Research Center, University of Wisconsin–Madison, Madison, Wisconsin, United States of America, 3 Neuroscience Training Program, University of Wisconsin–Madison, Madison, Wisconsin, United States of America, 4 Department of Medical Physics, University of Wisconsin–Madison, Madison, Wisconsin, United States of America, 5 Department of Pathology, The Sol Goldman Pancreatic Cancer Research Center, The Johns Hopkins University School of Medicine, Baltimore, Maryland, United States of America Abstract Glial cell line derived neurotrophic factor (GDNF) is a neurotrophic factor that has neuroprotective effects in animal models of Parkinson’s disease (PD) and has been proposed as a PD therapy. GDNF does not cross the blood brain barrier (BBB), and requires direct intracerebral delivery to be effective. Trojan horse technology, in which GDNF is coupled to a monoclonal antibody (mAb) against the human insulin receptor (HIR), has been proposed to allow GDNF BBB transport (Arm