a distinct peripheral blood monocyte phenotype is associated with parasite inhibitory activity in acute uncomplicated plasmodium falciparum malaria一个明显的外周血单核细胞表型与急性无并发症恶性疟原虫疟疾寄生虫抑制活动.pdfVIP

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a distinct peripheral blood monocyte phenotype is associated with parasite inhibitory activity in acute uncomplicated plasmodium falciparum malaria一个明显的外周血单核细胞表型与急性无并发症恶性疟原虫疟疾寄生虫抑制活动.pdf

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a distinct peripheral blood monocyte phenotype is associated with parasite inhibitory activity in acute uncomplicated plasmodium falciparum malaria一个明显的外周血单核细胞表型与急性无并发症恶性疟原虫疟疾寄生虫抑制活动

A Distinct Peripheral Blood Monocyte Phenotype Is Associated with Parasite Inhibitory Activity in Acute Uncomplicated Plasmodium falciparum Malaria 1,2 1 2 3 Pattamawan Chimma , Christian Roussilhon , Panudda Sratongno , Ronnatrai Ruangveerayuth , Kovit 2 ´ 1 4,5 1 Pattanapanyasat , Jean-Louis Perignon , David J. Roberts , Pierre Druilhe * 1 Bio-medical Parasitology Unit, Institut Pasteur, Paris, France, 2 Center of Excellence for Flow Cytometry, Office for Research and Development, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand, 3 Mae Sot Hospital, Mae Sot, Tak, Thailand, 4 Nuffield Department of Clinical Laboratory Sciences, Oxford, United Kingdom, 5 National Blood Service Oxford Centre, John Radcliffe Hospital, Oxford, United Kingdom Abstract Monocyte (MO) subpopulations display distinct phenotypes and functions which can drastically change during inflammatory states. We hypothesized that discrete MO subpopulations are induced during malaria infection and associated with anti-parasitic activity. We characterized the phenotype of blood MO from healthy malaria-exposed individuals and that of patients with acute uncomplicated malaria by flow cytometry. In addition, MO defense function was evaluated by an in vitro antibody dependent cellular inhibition (ADCI) assay. At the time of admission, the percentages and absolute numbers of CD16+ + + MO, and CCR2 CX3CR