a novel statistical algorithm for gene expression analysis helps differentiate pregnane x receptor-dependent and independent mechanisms of toxicity一个新颖的统计算法用于基因表达分析有助于区分孕烷x receptor-dependent和独立的毒性机制.pdfVIP

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a novel statistical algorithm for gene expression analysis helps differentiate pregnane x receptor-dependent and independent mechanisms of toxicity一个新颖的统计算法用于基因表达分析有助于区分孕烷x receptor-dependent和独立的毒性机制.pdf

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a novel statistical algorithm for gene expression analysis helps differentiate pregnane x receptor-dependent and independent mechanisms of toxicity一个新颖的统计算法用于基因表达分析有助于区分孕烷x receptor-dependent和独立的毒性机制

A Novel Statistical Algorithm for Gene Expression Analysis Helps Differentiate Pregnane X Receptor- Dependent and Independent Mechanisms of Toxicity 1 1 1 1 2 2 M. Ann Mongan *, Robert T. Dunn II , Steven Vonderfecht , Nancy Everds , Guang Chen , Cheng Su , 1 1 1 1 1 Marnie Higgins-Garn , Yuan Chen , Cynthia A. Afshari , Toni L. Williamson , Linda Carlock , Christopher 1 1 1 1 1 1 DiPalma , Suzanne Moss , Jeanine Bussiere , Charles Qualls Jr. , Yudong D. He , Hisham K. Hamadeh 1 Comparative Biology and Safety Sciences, Amgen Inc., Thousand Oaks, California, United States of America, 2 Research and Translational Sciences Biostatistics, Amgen Inc., Seattle, Washington, United States of America Abstract Genome-wide gene expression profiling has become standard for assessing potential liabilities as well as for elucidating mechanisms of toxicity of drug candidates under development. Analysis of microarray data is often challenging due to the lack of a statistical model that is amenable to biological variation in a small number of samples. Here we present a novel non-parametric algorithm that requires minimal assumptions about the data distribution. Our method for determining differential expression consists of two steps: 1) We apply a nominal threshold on fold change and platform p-value to designate whether a gene is differentially expressed in each treated and control sample relative to the averaged control pool, and 2) We compared the num