原创力文档a point mutation in a herpesvirus polymerase determines neuropathogenicity点突变在疱疹病毒聚合酶决定neuropathogenicity.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
a point mutation in a herpesvirus polymerase determines neuropathogenicity点突变在疱疹病毒聚合酶决定neuropathogenicity
A Point Mutation in a Herpesvirus Polymerase
Determines Neuropathogenicity
1 2 3 4 5 2
Laura B. Goodman , Arianna Loregian , Gillian A. Perkins , Josie Nugent , Elizabeth L. Buckles , Beatrice Mercorelli ,
4¤a ` 2 4¤b 1* 4¤c
Julia H. Kydd , Giorgio Palu , Ken C. Smith , Nikolaus Osterrieder , Nicholas Davis-Poynter
1 Department of Microbiology and Immunology, Cornell University, Ithaca, New York, United States of America, 2 Department of Histology, Microbiology and Medical
Biotechnologies, University of Padua, Padua, Italy, 3 Department of Clinical Sciences, Cornell University, Ithaca, New York, United States of America, 4 Centre for Preventive
Medicine, Animal Health Trust, Newmarket, United Kingdom, 5 Department of Biomedical Sciences, Cornell University, Ithaca, New York, United States of America
Infection with equid herpesvirus type 1 (EHV-1) leads to respiratory disease, abortion, and neurologic disorders in
horses. Molecular epidemiology studies have demonstrated that a single nucleotide polymorphism resulting in an
amino acid variation of the EHV-1 DNA polymerase (N752/D752) is significantly associated with the neuropathogenic
potential of naturally occurring strains. To test the hypothesis that this single amino acid exchange by itself influences
neuropathogenicity, we generated recombinant viruses with differing polymerase sequences. Here we show that the
N752 mutant virus caused no neurologic signs in the natural host, while the D752 virus was able to cause inflammation
of the central nervous system and ataxia. Neurologic disease induced by the D752 virus was
您可能关注的文档
- a new approach for using genome scans to detect recent positive selection in the human genome新方法使用基因组扫描来检测最近的积极的选择在人类基因组中.pdf
- a new ant species of the genus tetramorium mayr, 1855 (hymenoptera formicidae) from saudi arabia, with a revised key to the arabian species属的一个新的蚂蚁tetramorium娃,1855(膜翅目蚁科)从沙特阿拉伯,阿拉伯修订关键物种.pdf
- a neutralizing human monoclonal antibody protects against lethal disease in a new ferret model of acute nipah virus infection人类单克隆抗体中和预防致命性疾病的新雪貂的急性尼帕病毒感染模型.pdf
- a new avenue for classification and prediction of olive cultivars using supervised and unsupervised algorithms新大道橄榄品种使用监督和非监督分类和预测算法.pdf
- a new acoustic portal into the odontocete ear and vibrational analysis of the tympanoperiotic complex一个新的声学门户的odontocete耳朵和振动分析tympanoperiotic复杂.pdf
- a new benzofuran glucoside from ficus tikoua bur一个新的香豆酮甙从榕树tikoua钻.pdf
- a new battery energy storage chargingdischarging scheme for wind power producers in real-time markets风力发电的新电池储能chargingdischarging方案实时市场的生产商.pdf
- a new approach to age-period-cohort analysis using partial least squares regression the trend in blood pressure in the glasgow alumni cohortage-period-cohort分析新方法使用偏最小二乘回归的趋势在格拉斯哥的血压校友群.pdf
- a new bedt-ttf-based organic charge transfer salt with a new anionic strong acceptor, n,n'-disulfo-1,4-benzoquinonediimine新的bedt-ttf-based有机电荷转移盐阴离子受体,n,n ' -disulfo-1 4-benzoquinonediimine.pdf
- a new approach to measure volatility in energy markets一种新的方法来衡量能源市场的波动.pdf
- a point mutation in the hair cell nicotinic cholinergic receptor prolongs cochlear inhibition and enhances noise protection头发的点突变细胞烟碱胆碱能受体延长耳蜗抑制和增强噪音保护.pdf
- a phenome-based functional analysis of transcription factors in the cereal head blight fungus, fusarium graminearumphenome-based功能分析转录因子的谷物疫病菌,镰刀菌素graminearum.pdf
- a picture on the wall innovative mapping reveals cold-water coral refuge in submarine canyon墙上的一幅创新映射显示海底峡谷的冷水珊瑚保护区.pdf
- a polarized atmospheric radiative transfer model for calculations of spectra of the stokes parameters of shortwave radiation based on the line-by-line and monte carlo methods极化大气辐射传输模型计算光谱的短波辐射的斯托克斯参数的基础上,逐行和蒙特卡罗方法.pdf
- a plasma survey using 38 pfemp1 domains reveals frequent recognition of the plasmodium falciparum antigen var2csa among young tanzanian children等离子体调查使用38 pfemp1域显示频繁的恶性疟原虫抗原var2csa年轻人坦桑尼亚的孩子.pdf
- a plasmodium whole-genome synteny map indels and synteny breakpoints as foci for species-specific genes疟原虫全基因组同线性映射indels和同线性断点作为种特异的基因的焦点.pdf
- a policy-driven large scale ecological restoration quantifying ecosystem services changes in the loess plateau of china一个策略驱动的大规模生态修复量化在中国的黄土高原生态系统服务变化.pdf
- a p-loop mutation in gα subunits prevents transition to the active state implications for g-protein signaling in fungal pathogenesis在gαp-loop突变子单元防止过渡到真菌致病蛋白信号的活动状态的影响.pdf
- a polymorphism in the hla-dpb1 gene is associated with susceptibility to multiple sclerosishla-dpb1基因的多态性与对多发性硬化症的易感性有关.pdf
- a polynomial-time reduction from the 3sat problem to the generalized string puzzle problem多项式时间减少3 sat问题的广义字符串难题问题.pdf
文档评论（0）