原创力文档a realistic validation study of a new nitrogen multiple-breath washout system一个现实的验证研究一个新的氮multiple-breath冲洗系统.pdfVIP
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a realistic validation study of a new nitrogen multiple-breath washout system一个现实的验证研究一个新的氮multiple-breath冲洗系统
A Realistic Validation Study of a New Nitrogen Multiple-
Breath Washout System
1 2 1 3 4
Florian Singer *, Birgitta Houltz , Philipp Latzin , Paul Robinson , Per Gustafsson
1 Division of Respiratory Medicine, Department of Paediatrics, University Children’s Hospital of Bern, Bern, Switzerland, 2 Department of Clinical Physiology, East Hospital,
Sahlgrenska University Hospital, Gothenburg, Sweden, 3 Department of Paediatrics, The Children’s Hospital at Westmead, Sydney, Australia, 4 Department of Paediatrics,
Central Hospital, Skoevde, Sweden
Abstract
Background: For reliable assessment of ventilation inhomogeneity, multiple-breath washout (MBW) systems should be
realistically validated. We describe a new lung model for in vitro validation under physiological conditions and the
assessment of a new nitrogen (N2)MBW system.
Methods: The N MBW setup indirectly measures the N fraction (F ) from main-stream carbon dioxide (CO ) and side-
2 2 N2 2
stream oxygen (O ) signals: F = 12F 2F 2F . For in vitro N MBW, a double chamber plastic lung model was filled
2 N2 O2 CO2 Argon 2
with water, heated to 37uC, and ventilated at various lung volumes, respiratory rates, and F . In vivo N MBW was
CO2 2
undertaken in triplets on two occasions in 30 healthy adults. Pri
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