原创力文档a novel hepatitis c virus genotyping method based on liquid microarray一种新型丙型肝炎病毒基因分型方法基于液体微阵列.pdfVIP
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a novel hepatitis c virus genotyping method based on liquid microarray一种新型丙型肝炎病毒基因分型方法基于液体微阵列
A Novel Hepatitis C Virus Genotyping Method Based on
Liquid Microarray
1,2 1,2 3,4 3 1,2
Cesar A. B. Duarte , Leonardo Foti , Sueli M. Nakatani , Irina N. Riediger , Celina O. Poersch ,
Daniela P. Pavoni1,2, Marco A. Krieger 1,2*
˜ ´ ´
1 Instituto Carlos Chagas-Fundac¸ao Oswaldo Cruz (FIOCRUZ), Curitiba, Brazil, 2 Instituto de Biologia Molecular do Parana (IBMP), Curitiba, Brazil, 3 Laboratorio Central do
˜ ´ ˜ ˜
Estado (LACEN-PR), Sao Jose dos Pinhais, Brazil, 4 Department of Gastroenterology, School of Medicine, University of Sao Paulo (USP), Sao Paulo, Brazil
Abstract
The strategy used to treat HCV infection depends on the genotype involved. An accurate and reliable genotyping method is
therefore of paramount importance. We describe here, for the first time, the use of a liquid microarray for HCV genotyping.
This liquid microarray is based on the 5 9UTR — the most highly conserved region of HCV — and the variable region NS5B
sequence. The simultaneous genotyping of two regions can be used to confirm findings and should detect inter-genotypic
recombination. Plasma samples from 78 patients infected with viruses with genotypes and subtypes determined in the
VersantTM HCV Genotype Assay LiPA (version I; Siemens Medical Solutions, Diagnostics Division, Fernwald, Germany) were
tested with our new liquid microarray method. This method successfully determined the genot
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