a robust and fast system for ctc computer-aided detection of colorectal lesions一个健壮的和快速的ctc系统计算机辅助检测结直肠病变.pdfVIP

Algorithms 2010, 3, 21 - 43; doi:10.3390/a3010021 OPEN ACCESS algorithms ISSN 1999-4893 /journal/algorithms Article A Robust and Fast System for CTC Computer-Aided Detection of Colorectal Lesions Greg Slabaugh , Xiaoyun Yang, Xujiong Ye, Richard Boyes and Gareth Beddoe Medicsight PLC, 66 Hammersmith Road, London, W14 8UD, UK; E-Mails: xiaoyun.yang@ (X.Y.Y.); xujiong.ye@ (X.J.Y.); richard.boyes@ (R.B.); gareth.beddoe@ (G.B.) Author to whom correspondence should be addressed; E-Mail: greg.slabaugh@; Tel.: +44-(0)207-605-1180; Fax: +44-(0)207-605-7951. Received: 9 November 2009; in revised form: 14 December 2009 / Accepted: 23 December 2009 / Published: 5 January 2010 Abstract: We present a complete, end-to-end computer-aided detection (CAD) system for identifying lesions in the colon, imaged with computed tomography (CT). This system includes facilities for colon segmentation, candidate generation, feature analysis, and classification. The algorithms have been designed to offer robust performance to variation in image data and patient preparation. By utilizing efficient 2D and 3D processing, software optimizations, multi-threading, feature selection, and an optimized cascade classifier, the CAD system quickly determines a set of detection marks. The colon CAD system has been validated on the largest set of data to date, and demonstrates excellent performance, in terms of its high sensitivity, low false positive rate, and computational efficiency. Keywords: CAD; colorectal lesion detection; pattern recognition 1. Int