a simple model of tetracycline antibiotic resistance in the aquatic environment (with application to the poudre river)四环素抗生素耐药性的一个简单的模型在水生环境中(poudre河与应用程序).pdfVIP
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a simple model of tetracycline antibiotic resistance in the aquatic environment (with application to the poudre river)四环素抗生素耐药性的一个简单的模型在水生环境中(poudre河与应用程序)
Int. J. Environ. Res. Public Health 2011, 8, 480-497; doi:10.3390/ijerph8020480
OPEN ACCESS
International Journal of
Environmental Research and
Public Health
ISSN 1660-4601
/journal/ijerph
Article
A Simple Model of Tetracycline Antibiotic Resistance in the
Aquatic Environment (with Application to the Poudre River)
Ferdi L. Hellweger *, Xiaodan Ruan and Sarah Sanchez
Center for Urban Environmental Studies, Department of Civil Environmental Engineering,
Northeastern University, 360 Huntington Ave, Boston, MA 02115, USA;
E-Mails: xiaodanruan@ (X.R.); sanchez.sa@ (S.S.)
* Author to whom correspondence should be addressed; E-Mail: ferdi@;
Tel.: +1-617-373-3992.
Received: 1 January 2011; in revised form: 20 January 2011 / Accepted: 10 February 2011 /
Published: 15 February 2011
Abstract: Antibiotic resistance is a major concern, yet it is unclear what causes the
relatively high densities of resistant bacteria in the anthropogenically impacted
environment. There are various possible scenarios (hypotheses): (A) Input of resistant
bacteria from wastewater and agricultural sources is significant, but they do not grow in the
environment; (B) Input of resistant bacteria is negligible, but the resistant bacteria
(exogenous or endogenous) grow due to the
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