a three-dimensional, magnetic and electroactive nanoprobe for amperometric determination of tumor biomarkers一个三维、磁性和电活性nanoprobe测量电流的测定肿瘤生物标志物.pdfVIP

a three-dimensional, magnetic and electroactive nanoprobe for amperometric determination of tumor biomarkers一个三维、磁性和电活性nanoprobe测量电流的测定肿瘤生物标志物.pdf

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a three-dimensional, magnetic and electroactive nanoprobe for amperometric determination of tumor biomarkers一个三维、磁性和电活性nanoprobe测量电流的测定肿瘤生物标志物

Int. J. Mol. Sci. 2011, 12, 362-375; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Article A Three-Dimensional, Magnetic and Electroactive Nanoprobe for Amperometric Determination of Tumor Biomarkers Linghua Meng 1, Ning Gan 1,*, Tianhua Li 1, Yuting Cao 1, Futao Hu 1 and Lei Zheng 2,* 1 The State Key Laboratory Base of Novel Functional Materials and Preparation Science, Faculty of Material Science and Chemical Engineering, Ningbo University, Ningbo, Zhejiang 315211, China; E-Mails: meng_ting_2008@163.com (L.M.); litianhua@ (T.L.); caoyuting@ (Y.C.); hufutao@ (F.H.) 2 Clinical Laboratory Center, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, China * Author to whom correspondence should be addressed; E-Mails: ganning@ (N.G.); nflab@163.com (L.Z.); Tel.: +86 574(N.G.); +86 20(L.Z.); Fax: +86 574(N.G.); +86 20(L.Z.). Received: 1 December 2010; in revised form: 30 December 2010 / Accepted: 7 January 2011 / Published: 14 January 2011 Abstract: A novel electrochemical immunosensor for tumor biomarker detection based on three-dimensional, magnetic and electroactive nanoprobes was developed in this study. To fabricate the nanoprobes, negatively charged Fe O nanoparticles (Fe O NPs) and gold 3 4 3 4 nanoparticles (Au NPs

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