affibody-dylight conjugates for in vivo assessment of her2 expression by near-infrared optical imagingaffibody-dylight轭合物的体内评价her2表达近红外光学成像.pdfVIP

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affibody-dylight conjugates for in vivo assessment of her2 expression by near-infrared optical imagingaffibody-dylight轭合物的体内评价her2表达近红外光学成像.pdf

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affibody-dylight conjugates for in vivo assessment of her2 expression by near-infrared optical imagingaffibody-dylight轭合物的体内评价her2表达近红外光学成像

Affibody-DyLight Conjugates for In Vivo Assessment of HER2 Expression by Near-Infrared Optical Imaging 1,2*.¤a 3.¤b 4,5 6,7 3. Rafal Zielinski , Moinuddin Hassan , Ilya Lyakhov , Danielle Needle , Victor Chernomordik , 1 3 1 3 Alejandra Garcia-Glaessner , Yasaman Ardeshirpour , Jacek Capala , Amir Gandjbakhche 1 Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, United States of America, 2 Department of Molecular Biology, The John Paul II Catholic University of Lublin, Lublin, Poland, 3 Section on Analytical and Functional Biophotonics, Program on Pediatric Imaging and Tissue Sciences, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland, United States of America, 4 Protein Chemistry Laboratory, SAIC-Frederick, Inc., National Cancer Institute, Frederick, Maryland, United States of America, 5 VARNISS, L.L.C., Frederick, Maryland, United States of America, 6 Center for Cancer Research, Nanobiology Program, National Cancer Institute, Frederick, Maryland, United States of America, 7 Protein Engineering Section, Macromolecular Crystallography Laboratory, NCI, Frederick, Maryland, United States of America Abstract Purpose: Amplification of the HER2/neu gene and/or overexpression of the corresponding protein have been identified in approximately 20% of invasive breast carcinomas. Assessment of HER2 expression in vivo would advance devel