acoustic radiation force impulse imaging for differentiation of thyroid nodules声辐射力脉冲成像的分化甲状腺结节.pdfVIP

Acoustic Radiation Force Impulse Imaging for Differentiation of Thyroid Nodules 1 1 1 1 2 3 Joerg Bojunga , Nina Dauth , Christian Berner , Gesine Meyer , Katharina Holzer , Lisa Voelkl , 4 5 1 1 Eva Herrmann , Hartmut Schroeter , Stefan Zeuzem , Mireen Friedrich-Rust * 1 Department of Internal Medicine 1, J.W. Goethe-University Hospital, Frankfurt, Germany, 2 Department of General and Visceral Surgery, J.W. Goethe-University Hospital, Frankfurt, Germany, 3 Institute of Pathology, J.W. Goethe-University Hospital, Frankfurt, Germany, 4 Institute of Biostatistics and Mathematical Modelling, Faculty of ¨ Medicine, J.W. Goethe-University, Frankfurt, Germany, 5 Praxis-Klinik fur Diagnostik (PKD) am Staedel, Frankfurt, Germany Abstract Background: Acoustic Radiation Force Impulse (ARFI)-Imaging is an ultrasound-based elastography method enabling quantitative measurement of tissue stiffness. The aim of the present study was to evaluate sensitivity and specificity of ARFI- imaging for differentiation of thyroid nodules and to compare it to the well evaluated qualitative real-time elastography (RTE). Methods: ARFI-imaging involves the mechanical excitation of tissue using acoustic pulses to generate localized displacements resulting in shear-wave propagation which is tracked using correlation-based methods and recorded in m/s. Inclusion criteria were: nodules $5 mm, and cytological/histological assessment. All patients received conventional ultrasound, r