a temporal role of type i interferon signaling in cd8+ t cell maturation during acute west nile virus infectioni型干扰素信号的时间作用cd8 + t细胞在急性感染西尼罗河病毒成熟.pdfVIP

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a temporal role of type i interferon signaling in cd8+ t cell maturation during acute west nile virus infectioni型干扰素信号的时间作用cd8 + t细胞在急性感染西尼罗河病毒成熟.pdf

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atemporalroleoftypeiinterferonsignalingincd8tcellmaturationduringacutewestnilevirusinfectioni型干扰素信号的时间作用cd8t细胞在急性感染西尼罗河病毒成熟

A Temporal Role Of Type I Interferon Signaling in CD8+ T Cell Maturation during Acute West Nile Virus Infection 1 1¤ 1 1 1,2 Amelia K. Pinto , Stephane Daffis , James D. Brien , Maria D. Gainey , Wayne M. Yokoyama , 2 2 2 1,2,3 Kathleen C. F. Sheehan , Kenneth M. Murphy , Robert D. Schreiber , Michael S. Diamond * 1 Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States of America, 2 Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri, United States of America, 3 Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, United States of America Abstract A genetic absence of the common IFN- a/ b signaling receptor (IFNAR) in mice is associated with enhanced viral replication and altered adaptive immune responses. However, analysis of IFNAR-/- mice is limited for studying the functions of type I IFN at discrete stages of viral infection. To define the temporal functions of type I IFN signaling in the context of infection by West Nile virus (WNV), we treated mice with MAR1-5A3, a neutralizing, non cell-depleting anti-IFNAR antibody. Inhibition of type I IFN signaling at or before day 2 after infection was associated with markedly enhanced viral burden, whereas treatment at day 4 had substantially less effect on WNV dissemination. While antibody treatment prior to infection resulted in massive expansion of virus-specific