a systems level, functional genomics analysis of chronic epilepsy系统层面,功能基因组学分析慢性癫痫.pdfVIP

A Systems Level, Functional Genomics Analysis of Chronic Epilepsy 1,2,3. 3,10. 3,5 3,9 8 Kellen D. Winden , Stanislav L. Karsten , Anatol Bragin , Lili C. Kudo , Lauren Gehman , Josephine Ruidera3, Daniel H. Geschwind 1,2,3,6,7*, Jerome Engel Jr.3,4,5* 1 Interdepartmental Program for Neuroscience, University of California Los Angeles, Los Angeles, California, United States of America, 2 Program in Neurogenetics, University of California Los Angeles, Los Angeles, California, United States of America, 3 Department of Neurology, University of California Los Angeles, Los Angeles, California, United States of America, 4 Department of Neurobiology, University of California Los Angeles, Los Angeles, California, United States of America, 5 The Brain Research Institute, University of California Los Angeles, Los Angeles, California, United States of America, 6 Semel Institute for Neuroscience and Human Behavior, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America, 7 Department of Human Genetics, University of California Los Angeles, Los Angeles, California, United States of America, 8 Department of Microbiology, Immunology, and Molecular Genetics, University of California Los Angeles, Los Angeles, California, United States of America, 9 NeuroIndx Inc., Signal Hill, California, United States of America, 10 Division of Neuroscience Research, Department of Neurology, Harbor-UCLA Medical Center, Torrance, California, United States of America Abstract Neither the molecular basis of the pathologic tendency of neuronal circuits to generate spontaneous seizures (epileptogenicity) nor anti-epilepto