acquired antibody responses against plasmodium vivax infection vary with host genotype for duffy antigen receptor for chemokines (darc)获得抗体反应对间日疟原虫感染随宿主基因型对达菲抗原趋化因子受体(darc).pdfVIP
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acquired antibody responses against plasmodium vivax infection vary with host genotype for duffy antigen receptor for chemokines (darc)获得抗体反应对间日疟原虫感染随宿主基因型对达菲抗原趋化因子受体(darc)
Acquired Antibody Responses against Plasmodium vivax
Infection Vary with Host Genotype for Duffy Antigen
Receptor for Chemokines (DARC)
1 2 2 2 3 3
Amanda Maestre , Carlos Muskus , Victoria Duque , Olga Agudelo , Pu Liu , Akihide Takagi , Francis B.
4 4 5 6 7 2
Ntumngia , John H. Adams , Kim Lee Sim , Stephen L. Hoffman , Giampietro Corradin , Ivan D. Velez ,
Ruobing Wang3*
´
1 Grupo Salud y Comunidad, Facultad de Medicina, Universidad de Antioquia, Medellın, Colombia, 2 Programa de Estudio y Control de Enfermedades Tropicales (PECET),
´
Facultad de Medicina, Universidad de Antioquia, Medellın, Colombia, 3 Seattle Biomedical Research Institute (SBRI), Seattle, Washington, United States of America,
4 University of South Florida, Tampa, Florida, United States of America, 5 Protein Potential LLC., Rockville, Maryland, United States of America, 6 Sanaria, Rockville,
´
Maryland, United States of America, 7 Department of Biochemistry, Universite de Lausanne, Lausanne, Switzerland
Abstract
Background: Polymorphism of the Duffy Antigen Receptor for Chemokines (DARC) is associated with susceptibility to and
the severity of Plasmodium vivax malaria in humans. P. vivax uses DARC to invade erythrocytes. Individuals lacking DARC are
‘resistant’ to P. vivax erythrocytic infection. However, susceptibility to P. vivax in DARC+ individuals is reported to vary
be
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