原创力文档acquired obesity is associated with changes in the serum lipidomic profile independent of genetic effects – a monozygotic twin study收购了肥胖与血清lipidomic剖面的变化独立于基因的影响,同卵双胞胎的研究.pdfVIP
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acquired obesity is associated with changes in the serum lipidomic profile independent of genetic effects – a monozygotic twin study收购了肥胖与血清lipidomic剖面的变化独立于基因的影响,同卵双胞胎的研究
Acquired Obesity Is Associated with Changes in the
Serum Lipidomic Profile Independent of Genetic Effects –
A Monozygotic Twin Study
¨ 1,2,3 4 1 ¨ 4 ¨ 2 3,5 ˇ ˇ 4
Kirsi H. Pietilainen , Marko Sysi-Aho , Aila Rissanen , Tuulikki Seppanen-Laakso , Hannele Yki-Jarvinen , Jaakko Kaprio , Matej Oresic *
1 Obesity Research Unit, Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland, 2 Department of Medicine, Division of
Diabetes, Helsinki University Central Hospital, Helsinki, Finland, 3 Finnish Twin Cohort Study, Department of Public Health, University of Helsinki,
Helsinki, Finland, 4 VTT Technical Research Centre of Finland, Espoo, Finland, 5 Department of Mental Health and Alcohol Research, National Public
Health Institute, Helsinki, Finland
Both genetic and environmental factors are involved in the etiology of obesity and the associated lipid disturbances. We
determined whether acquired obesity is associated with changes in global serum lipid profiles independent of genetic factors
in young adult monozygotic (MZ) twins. 14 healthy MZ pairs discordant for obesity (10 to 25 kg weight difference) and ten
weight concordant control pairs aged 24–27 years were identified from a large population-based study. Insulin sensitivity was
assessed by the euglycemic clamp technique, and body composition by DEXA (% body fat) and by MRI (subcutaneous and
intra-abdominal fat). Global characterization of lipid molecular species in serum was performed by a lipidomics strategy using
liquid chromatography coupled to mass spectrometry. Obesity, independent of genetic influences, was primarily related to
increases in lysophosph
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