acquisition of complement inhibitor serine protease factor i and its cofactors c4b-binding protein and factor h by prevotella intermedia收购补丝氨酸蛋白酶抑制剂的因素我和它的代数余子式c4b-binding蛋白质和普氏菌因子h的媒介物.pdfVIP

Acquisition of Complement Inhibitor Serine Protease Factor I and Its Cofactors C4b-Binding Protein and Factor H by Prevotella intermedia 1¤ 1 2 3,4 5 1 Sven Malm , Monika Jusko , Sigrun Eick , Jan Potempa , Kristian Riesbeck , Anna M. Blom * ˚ ¨ 1 Section of Medical Protein Chemistry, Department of Laboratory Medicine, Skane University Hospital, Lund University, Malmo, Sweden, 2 Laboratory of Oral Microbiology, Department of Periodontology, University of Bern, Bern, Switzerland, 3 Faculty of Biochemistry, Biophysics and Biotechnology, Department of Microbiology, Jagiellonian University, Krakow, Poland, 4 Center of Oral Health and Systemic Diseases, University of Louisville Dental School, Louisville, Kentucky, United States of ˚ ¨ America, 5 Medical Microbiology, Department of Laboratory Medicine, Skane University Hospital, Lund University, Malmo, Sweden Abstract Infection with the Gram-negative pathogen Prevotella intermedia gives rise to periodontitis and a growing number of studies implies an association of P. intermedia with rheumatoid arthritis. The serine protease Factor I (FI) is the central inhibitor of complement degrading complement components C3b and C4b in the presence of cofactors such as C4b- binding protein (C4BP) and Factor H (FH). Yet, the significance of complement inhibitor acquisition in P. intermedia infection and FI binding by Gram-negative pathogens