原创力文档age affects quantity but not quality of antibody responses after vaccination with an inactivated flavivirus vaccine against tick-borne encephalitis年龄影响数量而不是质量的接种疫苗后抗体反应对蜱传脑炎灭活黄病毒疫苗.pdfVIP
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age affects quantity but not quality of antibody responses after vaccination with an inactivated flavivirus vaccine against tick-borne encephalitis年龄影响数量而不是质量的接种疫苗后抗体反应对蜱传脑炎灭活黄病毒疫苗
Age Affects Quantity but Not Quality of Antibody
Responses after Vaccination with an Inactivated
Flavivirus Vaccine against Tick-Borne Encephalitis
1 1 2 2 1
Karin Stiasny *, Judith H. Aberle , Michael Keller , Beatrix Grubeck-Loebenstein , Franz X. Heinz
1 Department of Virology, Medical University of Vienna, Vienna, Austria, 2 Institute for Biomedical Aging Research, Austrian Academy of Sciences, Innsbruck, Austria
Abstract
The impairment of immune functions in the elderly (immunosenescence) results in post-vaccination antibody titers that are
significantly lower than in young individuals. It is, however, a controversial question whether also the quality of antibodies
declines with age. In this study, we have therefore investigated the age-dependence of functional characteristics of
antibody responses induced by vaccination with an inactivated flavivirus vaccine against tick-borne encephalitis (TBE). For
this purpose, we quantified TBE virus-specific IgG and neutralizing antibody titers in post-vaccination sera from groups of
young and elderly healthy adults and determined antibody avidities and NT/ELISA titer ratios (functional activity). In contrast
to the quantitative impairment of antibody production in the elderly, we found no age-related differences in the avidity and
functional activity of antibodies induced by vaccination, which also appeared to be independent of the age at primary
immunization. There was no correlation between antibody avidity and NT/ELISA ratios suggesting that additional factors
affect the quality of polyclonal responses, independent of age. Our work indicates that healthy elderly people are able to
produce antibodies in response to vaccination with s
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