原创力文档amiloride enhances antigen specific ctl by faciliting hbv dna vaccine entry into cells阿米洛利增强抗原特异性ctl faciliting hbv dna疫苗进入细胞.pdfVIP
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amiloride enhances antigen specific ctl by faciliting hbv dna vaccine entry into cells阿米洛利增强抗原特异性ctl faciliting hbv dna疫苗进入细胞
Amiloride Enhances Antigen Specific CTL by Faciliting
HBV DNA Vaccine Entry into Cells
1 2 1 1 1 1 1
Shuang Geng , Yiwei Zhong , Shuang Wang , Hu Liu , Qiang Zou , Xiaoping Xie , Chaofan Li , Qingling
3 3 1,2
Yu , Zhonghuai He , Bin Wang *
1 State Key Laboratory for Agro-Biotechnology, China Agricultural University, Beijing, China, 2 Key laboratory of Medical Molecular Virology of MOH and MOE, Shanghai
Medical College, Fudan University, Shanghai, China, 3 Beijing Advaccine Biotechnology, Beijing, China
Abstract
The induction of relatively weak immunity by DNA vaccines in humans can be largely attributed to the low efficiency of
transduction of somatic cells. Although formulation with liposomes has been shown to enhance DNA transduction of
cultured cells, little, if any, effect is observed on the transduction of somatic tissues and cells. To improve the rate of
transduction, DNA vaccine delivery by gene gun and the recently developed electroporation techniques have been
employed. We report here that to circumvent requirement for such equipment, amiloride, a drug that is prescribed for
hypertension treatment, can accelerate plasmid entry into antigen presenting cells (APCs) both in vitro and in vivo. The
combination induced APCs more dramatically in both maturation and cytokine secretion. Amiloride enhanced development
of full CD8 cytolytic function including induction of high levels of antigen specific CTL and expression of IFN-
c+perforin+granzymeB+ in CD
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