aerosol generating procedures and risk of transmission of acute respiratory infections to healthcare workers a systematic review气溶胶生成过程和风险的急性呼吸道感染的传播卫生保健工作者系统回顾.pdfVIP
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Aerosol Generating Procedures and Risk of Transmission
of Acute Respiratory Infections to Healthcare Workers: A
Systematic Review
1 1 1 2 2,3
Khai Tran *, Karen Cimon , Melissa Severn , Carmem L. Pessoa-Silva , John Conly
1 Canadian Agency for Drugs and Technologies in Health (CADTH), Ottawa, Ontario, Canada, 2 World Health Organization (WHO), Geneva, Switzerland, 3 Departments of
Medicine, Microbiology, Immunology and Infectious Diseases, Pathology Laboratory Medicine, and the Calvin, Phoebe and Joan Synder Institute of Infection, Immunity
and Inflammation, Faculty of Medicine, University of Calgary, Calgary, Canada
Abstract
Aerosol generating procedures (AGPs) may expose health care workers (HCWs) to pathogens causing acute respiratory
infections (ARIs), but the risk of transmission of ARIs from AGPs is not fully known. We sought to determine the clinical
evidence for the risk of transmission of ARIs to HCWs caring for patients undergoing AGPs compared with the risk of
transmission to HCWs caring for patients not undergoing AGPs. We searched PubMed, EMBASE, MEDLINE, CINAHL, the
Cochrane Library, University of York CRD databases, EuroScan, LILACS, Indian Medlars, Index Medicus for SE Asia,
international health technology agencies and the Internet in all languages for articles from 01/01/1990 to 22/10/2010.
Independent reviewers screened abstracts using pre-defined criteria, obtained full-text articles, selected relevant studies,
and abstracted data. Disagreements were resolved by consensus. The outcome of interest was risk of ARI transmission. The
quality of evidence was rated using the GRADE system. We identified 5 case-control and 5 retrospective co
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