antibody repertoires in humanized nod-scid-il2rγnull mice and human b cells reveals human-like diversification and tolerance checkpoints in the mouse抗体在人性化体验nod-scid-il2rγnull老鼠和人类b细胞显示人类多元化和宽容检查点的老鼠.pdfVIP

Antibody Repertoires in Humanized NOD-scid-IL2Rcnull Mice and Human B Cells Reveals Human-Like Diversification and Tolerance Checkpoints in the Mouse 1 2 3 4 5 6 Gregory C. Ippolito , Kam Hon Hoi , Sai T. Reddy , Sean M. Carroll , Xin Ge , Tobias Rogosch , 6 7 8 9 Michael Zemlin , Leonard D. Shultz , Andrew D. Ellington , Carla L. VanDenBerg , George Georgiou1,2,4,8* 1 Section of Molecular Genetics and Microbiology, University of Texas at Austin, Austin, Texas, United States of America, 2 Department of Biomedical Engineering, ¨ University of Texas at Austin, Austin, Texas, United States of America, 3 Department of Biosystems Science and Engineering, Eidgenossische Technische Hochschule Zurich, Zurich, Switzerland, 4 Department of Chemical Engineering, University of Texas at Austin, Austin, Texas, United States of America, 5 Chemical and Environmental Engineering, University of California, Riverside, California, United States of America, 6 Department of Pediatrics, Philips-University, Marburg, Germany, 7 The Jackson Laboratory, Bar Harbor, Maine, United States of America, 8 Institute for Cellular and Molecular Biology, University of Texas at Austin, Austin, Texas, United States of America, 9 Department of Pharmacology and Toxicology, University of Texas at Austin, Austin, Texas, United States of America Abstract Immunodeficient mice reconstituted with human hematopoietic stem cells enable the in vivo