原创力文档antihyperglycemic and antioxidative effects of hydroxyethyl methylcellulose (hemc) and hydroxypropyl methylcellulose (hpmc) in mice fed with a high fat diet抗高血糖药和抗氧化效果的羟乙基甲基纤维素(hemc)和羟丙基甲基纤维素(hpmc)在与高脂肪饮食的老鼠.pdfVIP
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antihyperglycemic and antioxidative effects of hydroxyethyl methylcellulose (hemc) and hydroxypropyl methylcellulose (hpmc) in mice fed with a high fat diet抗高血糖药和抗氧化效果的羟乙基甲基纤维素(hemc)和羟丙基甲基纤维素(hpmc)在与高脂肪饮食的老鼠
Int. J. Mol. Sci. 2012, 13, 3738-3750; doi:10.3390/ijm
OPEN ACCESS
International Journal of
Molecular Sciences
ISSN 1422-0067
/journal/ijms
Article
Antihyperglycemic and Antioxidative Effects of Hydroxyethyl
Methylcellulose (HEMC) and Hydroxypropyl Methylcellulose
(HPMC) in Mice Fed with a High Fat Diet
Su Jeong Ban 1, Catherine W. Rico 1, In Chul Um 2 and Mi Young Kang 1,*
1 Department of Food Science and Nutrition, Kyungpook National University, Daegu 702-701, Korea;
E-Mails: crystal_hoi@ (S.J.B.); ckwrico@ (C.W.R.)
2 Department of Natural Fiber Science, Kyungpook National University, Daegu 702-701, Korea;
E-Mail: icum@knu.ac.kr
* Author to whom correspondence should be addressed; E-Mail: mykang@knu.ac.kr;
Tel./Fax: +82-53-950-6235.
Received: 2 November 2011; in revised form: 2 March 2012 / Accepted: 16 March 2012 /
Published: 21 March 2012
Abstract: The effect of dietary feeding of hydroxyethyl methylcellulose (HEMC) and
hydroxypropyl methylcellulose (HPMC) on the glucose metabolism and antioxidative
status in mice under high fat diet conditions was investigated. The mice were randomly
divided and given experimental diets for six weeks: normal control (NC group), high fat
(HF group), and high fat supplemented with either HEMC (HF+HEMC group) or HPMC
(HF+HPMC group). At the end of the experimental period, the HF group exhibited
markedly higher blood glucose and i
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