an rna interference lethality screen of the human druggable genome to identify molecular vulnerabilities in epithelial ovarian cancer人类制药基因组的rna干扰杀伤力屏幕识别分子漏洞在卵巢癌上皮.pdfVIP

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an rna interference lethality screen of the human druggable genome to identify molecular vulnerabilities in epithelial ovarian cancer人类制药基因组的rna干扰杀伤力屏幕识别分子漏洞在卵巢癌上皮.pdf

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an rna interference lethality screen of the human druggable genome to identify molecular vulnerabilities in epithelial ovarian cancer人类制药基因组的rna干扰杀伤力屏幕识别分子漏洞在卵巢癌上皮

An RNA Interference Lethality Screen of the Human Druggable Genome to Identify Molecular Vulnerabilities in Epithelial Ovarian Cancer 1,2. 1,3. 4 5 6 Geetika Sethi , Harsh B. Pathak , Hong Zhang , Yan Zhou , Margret B. Einarson , 7 8 7 1,3 Vinod Vathipadiekal , Sumedha Gunewardena , Michael J. Birrer , Andrew K. Godwin * 1 Department of Pathology and Laboratory Medicine, University of Kansas Medical Center, Kansas City, Kansas, United States of America, 2 Department of Biochemistry, Drexel University College of Medicine, Philadelphia, Pennsylvania, United States of America, 3 University of Kansas Cancer Center, Kansas City, Kansas, United States of America, 4 Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America, 5 Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America, 6 Translational Core Facility, Fox Chase Cancer Center, Philadelphia, Pennsylvania, United States of America, 7 Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, United States of America, 8 Molecular and Integrative Physiology, University of Kansas Medical Center, Kansas City, Kansas, United States of America Abstract Targeted therapies have been used to combat many tumor types; however, few have effectively improved the overall survival in women with epithelial ovarian cancer, begging for a better understanding of this deadly disease and identification of essential drivers of tumorigenesis that can be targeted effectively. The