antiparasitic bromotyrosine derivatives from the marine sponge verongula rigida抗bromotyrosine衍生品从海军海绵verongula rigida.pdfVIP

Mar. Drugs 2011, 9, 1902-1913; doi:10.3390/md9101902 OPEN ACCESS Marine Drugs ISSN 1660-3397 /journal/marinedrugs Article Antiparasitic Bromotyrosine Derivatives from the Marine Sponge Verongula rigida Elkin Galeano 1,*, Olivier P. Thomas 2, Sara Robledo 3, Diana Munoz 3 and Alejandro Martinez 1 1 Marine Natural Products Research Group, Pharmaceutical Chemistry Faculty, University of Antioquia, Medellin AA 1226, Colombia; E-Mail: amart@.co 2 Chemical Institute of Nice, UMR 6001 CNRS, University of Nice—Sophia Antipolis, Parc Valrose, 06108, Nice Cedex 02, France; E-Mail: olivier.Thomas@unice.fr 3 Program for the Study and Control of Tropical Diseases (PECET), University of Antioquia, Medellin AA 1226, Colombia; E-Mails: sara_robledo@ (S.R.); dhyana5@ (D.M.) * Author to whom correspondence should be addressed; E-Mail: elgaja@.co; Tel.: +57-4-2195456; Fax: +57-4-2195457. Received: 6 September 2011; in revised form: 21 September 2011 / Accepted: 30 September 2011 / Published: 14 October 2011 Abstract: Nine bromotyrosine-derived compounds were isolated from the Caribbean marine sponge Verongula rigida. Two of them, aeroplysinin-1 (1) and dihydroxyaerothionin (2), are known compounds for this species, and the other seven are unknown compounds for this species, namely: 3,5-dibromo-N,N,N-trimethyltyraminium (3), 3,5-dibromo-N,N,N, O-tetramethyltyraminium (4), purealidin R (5), 19-deoxyfistularin 3 (6), purealidin B (7), 11-hydroxyaerothionin (8) and fistularin-3 (9). Structural determina