application of ionic liquids in high performance reversed-phase chromatography离子液体应用于高性能反相色谱法.pdfVIP

Int. J. Mol. Sci. 2009, 10, 2591-2610; doi:10.3390/ijm OPEN ACCESS International Journal of Molecular Sciences ISSN 1422-0067 /journal/ijms Review Application of Ionic Liquids in High Performance Reversed-Phase Chromatography Ye Wang, Minglei Tian, Wentao Bi and Kyung Ho Row * Department of Chemical Engineering, Inha University, Incheon 402-751, Korea; E-Mails: wangye929@ (Y.W.); feitiandezhu@ (M.T.); bi_wentao@ (W.B.) * Author to whom correspondence should be addressed; E-Mail: rowkho@inha.ac.kr; Tel. +82-32-860-7470; Fax: +82-32-872-0959 Received: 27 April 2009; in revised form: 22 May 2009 / Accepted: 27 May 2009 / Published: 4 June 2009 Abstract: Ionic liquids, considered “green” chemicals, are widely used in many areas of analytical chemistry due to their unique properties. Recently, ionic liquids have been used as a kind of novel additive in separation and combined with silica to synthesize new stationary phase as separation media. This review will focus on the properties and mechanisms of ionic liquids and their potential applications as mobile phase modifier and surface-bonded stationary phase in reversed-phase high performance liquid chromatography (RP-HPLC). Ionic liquids demonstrate advantages and potential in chromatographic field. Keywords: ionic liquids; reversed-phase high performance liquid chromatog