原创力文档are plasma biomarkers of immune activation predictive of hiv progression a longitudinal comparison and analyses in hiv-1 and hiv-2 infections免疫激活的是等离子体生物标志物预测艾滋病的病程的纵向比较和分析在hiv - 1和hiv - 2感染.pdfVIP
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are plasma biomarkers of immune activation predictive of hiv progression a longitudinal comparison and analyses in hiv-1 and hiv-2 infections免疫激活的是等离子体生物标志物预测艾滋病的病程的纵向比较和分析在hiv - 1和hiv - 2感染
Are Plasma Biomarkers of Immune Activation Predictive
of HIV Progression: A Longitudinal Comparison and
Analyses in HIV-1 and HIV-2 Infections?
1 1 1,4 2 1
Samuel Nyamweya , John Townend , Akram Zaman , Sarah Jane Steele , David Jeffries ,
3 1 1. 1 .
Sarah Rowland-Jones , Hilton Whittle , Katie L. Flanagan , Assan Jaye *
1 Medical Research Council (UK), Banjul, The Gambia, West Africa, 2 University of Toronto, Toronto, Canada, 3 Weatherall Institute of Molecular Medicine, Oxford, United
Kingdom, 4 Centre for Infections, Health Protection Agency, London, United Kingdom
Abstract
Background: Chronic immune activation is a hallmark of HIV infection and has been associated with disease progression.
Assessment of soluble biomarkers indicating immune activation provide clues into pathogenesis and hold promise for the
development of point-of-care monitoring of HIV in resource-poor-settings. Their evaluation in cohort resources is therefore
needed to further their development and use in HIV research.
Methodology/Principal Findings: Longitudinal evaluation of beta-2 microglobulin (b-2 m), neopterin and suPAR soluble
urokinase-type plasminogen activator receptor (suPAR) was performed with archived plasma samples to predict disease
progression and provided the first direct comparison of levels in HIV-1 and HIV-2 infections. At least 2095 samples from 137
HIV-1 and 198 HIV-2 subjects with starting CD4% of $28 and median follow up of 4 years were analysed. All biomarkers
were correlated negatively to CD4% and positively to viral load and to each other. Analyses in subjects living for $5 ye
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