在直肠癌组织中Id-2和MMP-9的表达与临床病理学指标的关系.docVIP

基金项目：邯郸市科学技术研究与发展计划，编号：1123108080-4 第一作者： 单铁英( 1975) , 女, , 副教授, 主要从事肿瘤学研究。E-mail: sty751218@163.com； 通讯地址：河北省邯郸市丛台路83号； 电话肠癌组织Id-2和MMP-9的表达临床病理学指标, 河北， 邯郸056002；2 海港医院，河北，秦皇岛市066000； 3 邯郸市中心医院，河北，邯郸056002） 摘要 目的 观察在人抑制因子-（Id-）和-9( MMP-9)的表达直肠癌临床病理学指标的关系。癌癌旁正常组织用免疫组织化学方法观察Id-2和MMP-9在癌癌旁正常组织中的表达水平，Spearman 相关检验检测 Id-2 与 MMP-9 表达存在有无相关性, 分析 Id-2 与MMP-9表达与直肠癌临床病理学指标之间的关系Id-2 在直肠癌旁正常黏膜组织癌组织阳性Id-2 在直肠癌旁正常黏膜组织癌组织P 0.05)，MMP-9 在直肠癌组织阳性癌旁正常黏膜组织vs 44.64%, P 0.05)。Spearman 相关检验检测 Id-2 与 MMP-9 表达存在相关性r = 0.393, P =0.003)；在直肠癌不同分化程度、TNM 分期和有无淋巴结转移, Id-2 和MMP-9 阳性P 0.05）；但是在不同年龄和性别上，其表达阳性P 0.05）。结论 Id-2 和 MMP-9 , 直肠癌组织中Id-2高表达可能是通过 MMP-9 途径来实现对肿瘤侵袭转移成起促进作用。 关键词 直肠癌；分化抑制因子-2；基质金属蛋白酶-9；免疫组织化学 The relationship between expression of Id-2 and MMP-9 and clinical pathology index in rectal cancer SHAN Tie-ying1, SHAN Tie-qiang2,YUE Feng3, Yuan Zheng1, WANG Fang1, et al (1 College of Medical Sciences,Hebei Engineering University,Handan 056002；2 Harbor Hospital, Qinhuangdao City 066000; 3 Central hospital of handan ,Handan 056002. China.) Abstract: Objective To observe the expression level of inhibitor of differentiation 2 (Id-2) and Matrix metalloproteinases-9 (MMP-9) in rectal cancer, analysis the correlation of the expression level of them, to study the relationship between the expression level of them and the clinical pathology indicators of rectal cancer. Methods Rectal cancer tissues and normal tissue adjacent to rectal cancer were obtained from the rectal cancer resection of 56 patients with rectal cancer, using immunohistochemical method to observe the expression level of Id-2 and MMP-9 in normal tissue adjacent to rectal cancer and rectal cancer; Spearman correlation test to detect the correlation between the expression level of Id-2 and MMP-9; Analysis the relationships the expression level of Id-2 and MMP-9 and the index of rectal cancer clinical pathology. Results The positive expression rate of Id-2 in normal tissue of adjacent to rectal cancer and colorectal c