原创力文档reactive oxygen species facilitate translocation of hormone sensitive lipase to the lipid droplet during lipolysis in human differentiated adipocytes活性氧促进激素敏感脂肪酶的易位在人类分化脂肪细胞脂类分解脂滴.pdfVIP
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reactive oxygen species facilitate translocation of hormone sensitive lipase to the lipid droplet during lipolysis in human differentiated adipocytes活性氧促进激素敏感脂肪酶的易位在人类分化脂肪细胞脂类分解脂滴
Reactive Oxygen Species Facilitate Translocation of
Hormone Sensitive Lipase to the Lipid Droplet During
Lipolysis in Human Differentiated Adipocytes
1 2 1 2 1
Sarah A. Krawczyk *, Jorge F. Haller , Tom Ferrante , Raphael A. Zoeller , Barbara E. Corkey
1 Departments of Medicine and Biochemistry, Boston University School of Medicine, Boston, Massachusetts, United States of America, 2 Department of Physiology and
Biophysics, Boston University School of Medicine, Boston, Massachusetts, United States of America
Abstract
In obesity, there is an increase in reactive oxygen species (ROS) within adipose tissue caused by increases in inflammation
and overnutrition. Hormone sensitive lipase (HSL) is part of the canonical lipolytic pathway and critical for complete
lipolysis. This study hypothesizes that ROS is a signal that integrates regulation of lipolysis by targeting HSL. Experiments
were performed with human differentiated adipocytes from the subcutaneous depot. Antioxidants were employed as a tool
to decrease ROS, and it was found that scavenging ROS with diphenyliodonium, N-acetyl cysteine, or resveratrol decreased
lipolysis in adipocytes. HSL phosphorylation of a key serine residue, Ser552, as well as translocation of this enzyme from the
cytosol to the lipid droplet upon lipolytic stimulation were both abrogated by scavenging ROS. The phosphorylation status
of other serine residues on HSL were not affected. These findings are significant because they document that ROS
contributes to the physiological regulation of lipolysis via an effect on translocation. Such regulation could be useful in
developing new obesity therapies.
Citation: Krawczyk SA, Haller JF, Ferrante T, Zoeller RA, Corkey BE (2
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