原创力文档regulation of brown fat adipogenesis by protein tyrosine phosphatase 1b棕色脂肪脂肪形成的调节蛋白酪氨酸磷酸酶1 b.pdfVIP
- 1、原创力文档（book118）网站文档一经付费（服务费），不意味着购买了该文档的版权，仅供个人/单位学习、研究之用，不得用于商业用途，未经授权，严禁复制、发行、汇编、翻译或者网络传播等，侵权必究。。
- 2、本站所有内容均由合作方或网友上传，本站不对文档的完整性、权威性及其观点立场正确性做任何保证或承诺！文档内容仅供研究参考，付费前请自行鉴别。如您付费，意味着您自己接受本站规则且自行承担风险，本站不退款、不进行额外附加服务；查看《如何避免下载的几个坑》。如果您已付费下载过本站文档，您可以点击 这里二次下载。
- 3、如文档侵犯商业秘密、侵犯著作权、侵犯人身权等，请点击“版权申诉”（推荐），也可以打举报电话：400-050-0827(电话支持时间：9:00-18:30)。
- 4、该文档为VIP文档，如果想要下载，成为VIP会员后，下载免费。
- 5、成为VIP后，下载本文档将扣除1次下载权益。下载后，不支持退款、换文档。如有疑问请联系我们。
- 6、成为VIP后，您将拥有八大权益，权益包括：VIP文档下载权益、阅读免打扰、文档格式转换、高级专利检索、专属身份标志、高级客服、多端互通、版权登记。
- 7、VIP文档为合作方或网友上传，每下载1次， 网站将根据用户上传文档的质量评分、类型等，对文档贡献者给予高额补贴、流量扶持。如果你也想贡献VIP文档。上传文档
查看更多
regulation of brown fat adipogenesis by protein tyrosine phosphatase 1b棕色脂肪脂肪形成的调节蛋白酪氨酸磷酸酶1 b
Regulation of Brown Fat Adipogenesis by Protein
Tyrosine Phosphatase 1B
1. 1. 1 1 2¤ 1
Kosuke Matsuo , Ahmed Bettaieb , Naoto Nagata , Izumi Matsuo , Heike Keilhack , Fawaz G. Haj *
1 Nutrition Department, University of California Davis, Davis, California, United States of America, 2 Beth Israel Deaconess Medical Center, Harvard Medical School, Boston,
Massachusetts, United States of America
Abstract
Background: Protein-tyrosine phosphatase 1B (PTP1B) is a physiological regulator of insulin signaling and energy balance,
but its role in brown fat adipogenesis requires additional investigation.
Methodology/Principal Findings: To precisely determine the role of PTP1B in adipogenesis, we established preadipocyte
cell lines from wild type and PTP1B knockout (KO) mice. In addition, we reconstituted KO cells with wild type, substrate-
trapping (D/A) and sumoylation-resistant (K/R) PTP1B mutants, then characterized differentiation and signaling in these
cells. KO, D/A- and WT-reconstituted cells fully differentiated into mature adipocytes with KO and D/A cells exhibiting a
trend for enhanced differentiation. In contrast, K/R cells exhibited marked attenuation in differentiation and lipid
accumulation compared with WT cells. Expression of adipogenic markers PPARc, C/EBPa, C/EBPd, and PGC1a mirrored the
differentiation pattern. In addition, the differentiation deficit in K/R cells could be reversed completely by the PPARc
activator troglitazone. PTP1B deficiency enhanced insulin receptor (IR) and insulin receptor substrate 1 (IRS1) tyrosyl
phosphorylation, while K/R cells exhibited attenuated insuli
您可能关注的文档
- recombination hotspots flank the cryptococcus mating-type locus implications for the evolution of a fungal sex chromosome重组热点侧面的隐球菌接合型轨迹对真菌的进化性染色体的影响.pdf
- reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugged fitness landscape相互之间签署上位经常实验进化适应性突变引起的健身景观.pdf
- recombinant lysyl oxidase propeptide protein inhibits growth and promotes apoptosis of pre-existing murine breast cancer xenografts赖氨酰化氧前肽重组蛋白抑制增长和促进细胞凋亡的预先存在的小鼠乳腺癌异种移植.pdf
- recombination rate and selection strength in hiv intra-patient evolution重组率和选择在艾滋病毒intra-patient进化的力量.pdf
- reconsidering the sporulation characteristics of hypervirulent clostridium difficile binap1027重新考虑binap1027梭状芽胞杆菌hypervirulent的孢子形成特点.pdf
- recombination and population structure in salmonella enterica重组和沙门氏菌导致的人口结构.pdf
- reconciling the evidence on serum homocysteine and ischaemic heart disease a meta-analysis调和的证据对血清同型半胱氨酸和缺血性心脏病一个荟萃分析.pdf
- reconstitution of an infectious human endogenous retrovirus重组人类内源性逆转录病毒的传染性.pdf
- recombinational landscape and population genomics of caenorhabditis elegans人口重组景观和秀丽隐杆线虫的基因组.pdf
- recombining low homology, functionally rich regions of bacterial subtilisins by combinatorial fragment exchange重组同源性较低,功能上富裕地区的细菌枯草杆菌蛋白酶组合片段交换.pdf
- regulation of chemokine and chemokine receptor expression by pparγ in adipocytes and macrophages监管pparγ趋化因子和趋化因子受体表达的脂肪细胞和巨噬细胞.pdf
- regulated proteolytic processing of reelin through interplay of tissue plasminogen activator (tpa), adamts-4, adamts-5, and their modulators调节蛋白水解处理reelin通过相互作用的组织纤溶酶原激活物(tpa)adamts-4 adamts-5,他们的调节器.pdf
- regulation of clock-controlled genes in mammalsclock-controlled调节基因在哺乳动物.pdf
- regulation of cullin ring e3 ubiquitin ligases by cand1 in vivo监管cullin环e3泛素连接酶cand1体内.pdf
- regulation of cysteinyl leukotriene receptor 2 expression—a potential anti-tumor mechanism调节半胱氨酰白三烯受体2表达了潜在的抗肿瘤机制.pdf
- regulation of cox2 expression in mouse mammary tumor cells controls bone metastasis and pge2-induction of regulatory t cell migration监管cox2的表达在小鼠乳腺肿瘤细胞控制骨转移和pge2-induction调节性t细胞的迁移.pdf
- regulation of dna repair mechanism in human glioma xenograft cells both in vitro and in vivo in nude mice监管的dna修复机制在人类神经胶质瘤异种移植细胞在体外和体内都裸体小鼠.pdf
- regulation of dcc localization by htz-1h2a.z and dpy-30 does not correlate with h3k4 methylation levels监管dcc htz-1h2a本地化。.pdf
- regulation of early adipose commitment by zfp521早期脂肪zfp521承诺的监管.pdf
- regulation of budding yeast mating-type switching donor preference by the fha domain of fkh1监管出芽酵母接合型捐助偏好fkh1 fha域的转换.pdf
文档评论（0）