原创力文档regulation of cysteinyl leukotriene receptor 2 expression—a potential anti-tumor mechanism调节半胱氨酰白三烯受体2表达了潜在的抗肿瘤机制.pdfVIP
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regulation of cysteinyl leukotriene receptor 2 expression—a potential anti-tumor mechanism调节半胱氨酰白三烯受体2表达了潜在的抗肿瘤机制
Regulation of Cysteinyl Leukotriene Receptor 2
Expression—A Potential Anti-Tumor Mechanism
1 1 1 1 3 ¨ 2
Cecilia Magnusson , Astrid M. Bengtsson , Minghui Liu , Jian Liu , Yvonne Ceder , Roy Ehrnstrom ,
¨ 1*
Anita Sjolander
˚ ¨
1 Cell and Experimental Pathology, Department of Laboratory Medicine, Lund University, Skanes University Hospital, Malmo, Sweden, 2 Pathology, Department of
˚ ¨ ˚
Laboratory Medicine, Lund University, Skanes University Hospital, Malmo, Sweden, 3 Clinical Chemistry, Department of Laboratory Medicine, Lund University, Skanes
¨
University Hospital, Malmo, Sweden
Abstract
Background: The cysteinyl leukotrienes receptors (CysLTRs) are implicated in many different pathological conditions, such
as inflammation and cancer. We have previously shown that colon cancer patients with high CysLT R and low CysLT R
1 2
expression demonstrate poor prognosis. Therefore, we wanted to investigate ways for the transcriptional regulation of
CysLT2R, which still remains to be poorly understood.
Methodology/Principal Findings: We investigated the potential role of the anti-tumorigenic interferon a (IFN-a) and the
mitogenic epidermal growth factor (EGF) on CysLT2R regulation using non-transf
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