recrudescent plasmodium berghei from pregnant mice displays enhanced binding to the placenta and induces protection in multigravida复发的鼠从怀孕的老鼠显示增强的绑定在经产孕妇胎盘和诱发保护.pdfVIP

Recrudescent Plasmodium berghei from Pregnant Mice Displays Enhanced Binding to the Placenta and Induces Protection in Multigravida 1,4. 1. 2,4 ´ 1 ˜ Claudio R. F. Marinho , Rita Neres , Sabrina Epiphanio , Lıgia A. Gonc¸alves , Manuela Beirao 3 1 Catarino , Carlos Penha-Gonc¸alves * ˆ ´ 1 Instituto Gulbenkian de Ciencia, Oeiras, Portugal, 2 Unidade de Malaria, Instituto de Medicina Molecular, Universidade de Lisboa, Lisboa, Portugal, 3 Faculdade de ´ ˆ ´ ˜ farmacia, Universidade de Lisboa, Lisboa, Portugal, 4 Departamento de Ciencias Biologicas, Universidade Federal de Sao Paulo, Diadema, Brazil Abstract Pregnancy-associated malaria (PAM) is associated with placenta pathology and poor pregnancy outcome but the mechanisms that control the malaria parasite expansion in pregnancy are still poorly understood and not amenable for study in human subjects. Here, we used a set of new tools to re-visit an experimental mouse model of pregnancy-induced malaria recrudescence, BALB/c with chronic Plasmodium berghei infection. During pregnancy 60% of the pre-exposed primiparous females showed pregnancy-induced malaria recrudescence and we demonstrated that the recrudescent P. berghei show an unexpected enhancement of the adherence to placenta tissue sections with a marked specificity for CSA. Furthermore, we showed that the intensity of parasitemia in primigravida was quantitatively