randomized controlled trial of fish oil and montelukast and their combination on airway inflammation and hyperpnea-induced bronchoconstriction随机对照试验的鱼油和montelukast及其组合对气道炎症和hyperpnea-induced支气管收缩.pdfVIP

Randomized Controlled Trial of Fish Oil and Montelukast and Their Combination on Airway Inflammation and Hyperpnea-Induced Bronchoconstriction 1,4 1 1 2 Sandra Tecklenburg-Lund , Timothy D. Mickleborough *, Louise A. Turner , Alyce D. Fly , Joel M. Stager1, Gregory S. Montgomery3 1 Human Performance and Exercise Biochemistry Laboratory, Department of Kinesiology, Indiana University, Bloomington, Indiana, United States of America, 2 Department of Applied Health Science, Indiana University, Bloomington, Indiana, United States of America, 3 Indiana University School of Medicine, Indiana University, Indianapolis, Indiana, United States of America, 4 Health and Human Performance, Nebraska Wesleyan University, Lincoln, Nebraska, United States of America Abstract Background: Both fish oil and montelukast have been shown to reduce the severity of exercise-induced bronchoconstriction (EIB). The purpose of this study was to compare the effects of fish oil and montelukast, alone and in combination, on airway inflammation and bronchoconstriction induced by eucapnic voluntary hyperpnea (EVH) in asthmatics. Methods: In this model of EIB, twenty asthmatic subjects with documented hyperpnea-induced bronchoconstriction (HIB) entered a randomized double-blind trial. All subjects entered on their usual diet (pre-treatment, n = 20) and then were randomly assigned to receive either one active 10 mg montelukast tablet and 10 placebo fish oil capsules (n = 10) or one placebo montelukast tablet and 10 active fish oil capsules totaling 3.2 g EPA and 2.0 g DHA (n = 10) taken daily for 3-wk. Thereafter, all subjects (combination treatment; n = 20) underwent another 3-wk treat