原创力文档randomized trial of piperaquine with sulfadoxine-pyrimethamine or dihydroartemisinin for malaria intermittent preventive treatment in children随机试验的哌喹与双氢青蒿素含量测定磺胺多辛-乙胺嘧啶或间歇性预防治疗疟疾的儿童.pdfVIP
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randomized trial of piperaquine with sulfadoxine-pyrimethamine or dihydroartemisinin for malaria intermittent preventive treatment in children随机试验的哌喹与双氢青蒿素含量测定磺胺多辛-乙胺嘧啶或间歇性预防治疗疟疾的儿童
Randomized Trial of Piperaquine with Sulfadoxine-
Pyrimethamine or Dihydroartemisinin for Malaria
Intermittent Preventive Treatment in Children
1,2 2 1 3 1 3
Badara Cisse , Matthew Cairns , Ernest Faye , Ousmane NDiaye , Babacar Faye , Cecile Cames , Yue
4 2 ´ ˆ 2 3 3 2,5
Cheng , Maguette NDiaye , Aminata Colle Lo , Kirsten Simondon , Jean-Francois Trape , Oumar Faye ,
1 1 2 2
Jean Louis NDiaye , Oumar Gaye , Brian Greenwood , Paul Milligan *
1 Department of Parasitology and Mycology, Universite Cheikh Anta Diop, Dakar, Senegal, 2 London School of Hygiene and Tropical Medicine, London, United Kingdom,
3 Institut de Recherche pour le Developpement, Dakar, Senegal, 4 Xi’an Jiaotong University College of Medicine, Xi’an, China, 5 Ministere de la Sante, Senegal
Abstract
Background: The long terminal half life of piperaquine makes it suitable for intermittent preventive treatment for malaria
but no studies of its use for prevention have been done in Africa. We did a cluster randomized trial to determine whether
piperaquine in combination with either dihydroartemisin (DHA) or sulfadoxine-pyrimethamine (SP) is as effective, and better
tolerated, than SP plus amodiaquine (AQ), when used for intermittent preventive treatment in children delivered by
community health workers in a rural area of Senegal.
Methods: Treatments were delivered to children 3–59 months of age in their homes once per month during the
tra
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