randomized trial of artesunate+amodiaquine, sulfadoxine-pyrimethamine+amodiaquine, chlorproguanal-dapsone and sp for malaria in pregnancy in tanzania随机试验的青蒿琥酯+阿莫地喹,磺胺多辛-乙胺嘧啶+阿莫地喹chlorproguanal-dapsone和sp疟疾在坦桑尼亚的怀孕.pdfVIP

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randomized trial of artesunate+amodiaquine, sulfadoxine-pyrimethamine+amodiaquine, chlorproguanal-dapsone and sp for malaria in pregnancy in tanzania随机试验的青蒿琥酯+阿莫地喹,磺胺多辛-乙胺嘧啶+阿莫地喹chlorproguanal-dapsone和sp疟疾在坦桑尼亚的怀孕.pdf

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randomizedtrialofartesunateamodiaquine,sulfadoxine-pyrimethamineamodiaquine,chlorproguanal-dapsoneandspformalariainpregnancyintanzania随机试验的青蒿琥酯阿莫地喹,磺胺多辛-乙胺嘧啶阿莫地喹chlorproguanal-dapsone和sp疟疾在坦桑尼亚的怀孕

Randomized Trial of Artesunate+Amodiaquine, Sulfadoxine-Pyrimethamine+Amodiaquine, Chlorproguanal-Dapsone and SP for Malaria in Pregnancy in Tanzania 1,2 3,4 1 ˜ 5 1 Theonest K. Mutabingwa *, Kandi Muze , Rosalynn Ord , Marnie Briceno , Brian M. Greenwood , Chris Drakeley1, Christopher J. M. Whitty1 1 Department of Infectious and Tropical Diseases, London School of Hygiene Tropical Medicine, London, United Kingdom, 2 National Institute for Medical Research, Dar- es-Salaam, Tanzania, 3 Muheza Designated District Hospital, Muheza, Tanga Region, Tanzania, 4 Muhimbile Medical Centre, Dar-es-Salaam, Tanzania, 5 Department of Genome Sciences, University of Washington, Seattle, Washington, United States of America Abstract Background: Malaria in pregnancy is serious, and drug resistance in Africa is spreading. Drugs have greater risks in pregnancy and determining the safety and efficacy of drugs in pregnancy is therefore a priority. This study set out to determine the efficacy and safety of several antimalarial drugs and combinations in pregnant women with uncomplicated malaria. Methods: Pregnant women with non-severe, slide proven, falciparum malaria were randomised to one of 4 regimes: sulfadoxine-pyrimethamine [SP]; chlorproguanil-dapsone [CD]; SP+amodiaquine [SP+AQ] or amodiaquine+artesunate [AQ+AS]. Randomisation was on a 1:2:2:2 ratio. Women were admitted for treatment, and followed at days 7, 14, 21, 28 after the start of treatment, at delivery and 6 weeks after delivery to determine adverse events, clinical and parasitological outcomes. Primary outcome was parasitological failure by day 28. Results: 1433 pregnan