randomized, controlled intervention trial of male circumcision for reduction of hiv infection risk the anrs 1265 trial随机对照干预试验的男性包皮环切术感染艾滋病毒的风险降低艾滋病1265试验.pdfVIP

Open access, freely available online PLoS MEDICINE Randomized, Controlled Intervention Trial of Male Circumcision for Reduction of HIV Infection Risk: The ANRS 1265 Trial 1,2,3,4* 5 2,4 ¨ 2 ´ 2,4 6 Bertran Auvert , Dirk Taljaard , Emmanuel Lagarde , Joelle Sobngwi-Tambekou , Remi Sitta , Adrian Puren ˆ ´ ˆ 1 Hopital Ambroise-Pare, Assitance Publique—Hopitaux de Paris, Boulogne, France, 2 INSERM U 687, Saint-Maurice, France, 3 University Versailles Saint-Quentin, Versailles, France, 4 IFR 69, Villejuif, France, 5 Progressus, Johannesburg, South Africa, 6 National Institute for Communicable Disease, Johannesburg, South Africa Competing Interests: The authors A B S T R A C T have declared that no competing interests exist. Background Author Contributions: BA designed the study with DT, EL, and AP. DT Observational studies suggest that male circumcision may provide protection against HIV-1 and AP were responsible for infection. A randomized, controlled intervention trial was conducted in a general population of operational aspects, including South Africa to test this hypothesis. laboratory and field work and in- country administration of the study. BA monitored the study with input Methods and Findings from EL and wrote the paper with input from all authors. BA analyzed the data with RS, with inputs from A total of 3,274 uncircumcised men, aged 18–24 y, were randomized to a control or an JST. RS conducted the interim intervention group with follow-up visits at months 3, 12, a