原创力文档randomized, placebo-controlled trial of mipomersen in patients with severe hypercholesterolemia receiving maximally tolerated lipid-lowering therapy随机、安慰剂对照试验mipomersen严重高胆固醇血症患者接受最大限度容忍降脂治疗.pdfVIP
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randomized, placebo-controlled trial of mipomersen in patients with severe hypercholesterolemia receiving maximally tolerated lipid-lowering therapy随机、安慰剂对照试验mipomersen严重高胆固醇血症患者接受最大限度容忍降脂治疗
Randomized, Placebo-Controlled Trial of Mipomersen in
Patients with Severe Hypercholesterolemia Receiving
Maximally Tolerated Lipid-Lowering Therapy
1 2 3 4 5
Mary P. McGowan *, Jean-Claude Tardif , Richard Ceska , Lesley J. Burgess , Handrean Soran ,
6 7 8
Ioanna Gouni-Berthold , Gilbert Wagener , Scott Chasan-Taber
´
1 Cardiometabolic Risk Reduction and Research Center of New England, Bedford, New Hampshire, United States of America, 2 Montreal Heart Institute, Universite de
´
Montreal, Montreal, Quebec, Canada, 3 Centre for Preventive Cardiology, General Teaching Hospital and First Medical Faculty of Charles University in Prague, Prague,
Czech Republic, 4 Cardiology Unit, Stellenbosch University and Tygerberg Hospital, Parow, South Africa, 5 University Department of Medicine, Central Manchester
Foundation Trust, Manchester, United Kingdom, 6 Center of Endocrinology, Diabetes and Preventive Medicine, University of Cologne, Cologne, Germany, 7 Clinical
Research, Genzyme Corporation, Almere Stad Area, The Netherlands, 8 Biostatistics, Genzyme Corporation, Cambridge, Massachusetts, United States of America
Abstract
Objectives: Mipomersen, an antisense oligonucleotide targeting apolipoprotein B synthesis, significantly reduces LDL-C and
other atherogenic lipoproteins in familial hypercholesterolemia when added to ongoing maximally tolerated lipid-lowering
therapy. Safety and efficacy of mipomersen in patients with severe hypercholesterolemia was evaluated.
Methods and Resul
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