原创力文档recruitment kinetics of dna repair proteins mdc1 and rad52 but not 53bp1 depend on damage complexity招聘dna修复蛋白mdc1动力学和rad52但不是53 bp1取决于损伤的复杂性.pdfVIP
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recruitment kinetics of dna repair proteins mdc1 and rad52 but not 53bp1 depend on damage complexity招聘dna修复蛋白mdc1动力学和rad52但不是53 bp1取决于损伤的复杂性
Recruitment Kinetics of DNA Repair Proteins Mdc1 and
Rad52 but Not 53BP1 Depend on Damage Complexity
1 2 ¨ 1 1 1 2
Volker Hable , Guido A. Drexler , Tino Bruning , Christian Burgdorf , Christoph Greubel , Anja Derer ,
1 3 3 2 ¨ 1
Judith Seel , Hilmar Strickfaden , Thomas Cremer , Anna A. Friedl , Gunther Dollinger *
¨ ¨ ¨
1 Angewandte Physik und Messtechnik LRT2, UniBw-Munchen, Neubiberg, Germany, 2 Klinik und Poliklinik fur Strahlentherapie und Radioonkologie, LMU-Munchen,
¨ ¨
Munchen, Germany, 3 Department Biologie II, LMU-Munchen, Martinsried, Germany
Abstract
The recruitment kinetics of double-strand break (DSB) signaling and repair proteins Mdc1, 53BP1 and Rad52 into radiation-
induced foci was studied by live-cell fluorescence microscopy after ion microirradiation. To investigate the influence of
damage density and complexity on recruitment kinetics, which cannot be done by UV laser irradiation used in former
studies, we utilized 43 MeV carbon ions with high linear energy transfer per ion (LET = 370 keV/mm) to create a large fraction
of clustered DSBs, thus forming complex DNA damage, and 20 MeV protons with low LET (LET = 2.6 keV/mm) to create
mainly isolated DSBs. Kinetics for all three proteins was characterized by a time lag period T0 after irradiation, during which
no foci are formed. Subsequently, the proteins a
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