原创力文档rectangular coordination polymer nanoplates large-scale, rapid synthesis and their application as a fluorescent sensing platform for dna detection矩形配位聚合物nanoplates大规模、快速的合成及其应用程序作为荧光传感平台进行dna检测.pdfVIP
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rectangular coordination polymer nanoplates large-scale, rapid synthesis and their application as a fluorescent sensing platform for dna detection矩形配位聚合物nanoplates大规模、快速的合成及其应用程序作为荧光传感平台进行dna检测
Rectangular Coordination Polymer Nanoplates: Large-
Scale, Rapid Synthesis and Their Application as a
Fluorescent Sensing Platform for DNA Detection
1 1 1,2 3,4 3,4
Yingwei Zhang , Yonglan Luo , Jingqi Tian , Abdullah M. Asiri , Abdulrahman O. Al-Youbi , Xuping
Sun1,3,4*
1 State Key Lab of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Changchun, Jilin, People’s Republic of China, 2 Chinese Academy of Sciences,
Graduate School of the Chinese Academy of Sciences, Beijing, People’s Republic of China, 3 Chemistry Department, Faculty of Science, King Abdulaziz University, Jeddah,
Saudi Arabia, 4 Center of Excellence for Advanced Materials Research, King Abdulaziz University, Jeddah, Saudi Arabia
Abstract
In this paper, we report on the large-scale, rapid synthesis of uniform rectangular coordination polymer nanoplates (RCPNs)
assembled from Cu(II) and 4,49-bipyridine for the first time. We further demonstrate that such RCPNs can be used as a very
effective fluorescent sensing platform for multiple DNA detection with a detection limit as low as 30 pM and a high
selectivity down to single-base mismatch. The DNA detection is accomplished by the following two steps: (1) RCPN binds
dye-labeled single-stranded DNA (ssDNA) probe, which brings dye and RCPN into close proximity, leading to fluorescence
quenching; (2) Specific hybridization of the probe with its target generates a double-stranded DNA (dsDNA) which detaches
from RCPN, leading to fluorescence recovery. It suggests that this sensing system can well discriminate complementary and
mismatched DNA sequences. The exact mechanism of fluorescence quenching involved is elucidated experimentally and its
use in a human blo
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