recursive cluster elimination based support vector machine for disease state prediction using resting state functional and effective brain connectivity疾病状态递归消除集群基于支持向量机预测使用大脑静息状态的功能和有效的连接.pdfVIP

Recursive Cluster Elimination Based Support Vector Machine for Disease State Prediction Using Resting State Functional and Effective Brain Connectivity 1 2 2 3 3 Gopikrishna Deshpande , Zhihao Li , Priya Santhanam , Claire D. Coles , Mary Ellen Lynch , Stephan 4 2 Hamann , Xiaoping Hu * 1 Department of Electrical and Computer Engineering, Auburn University MRI Research Center, Auburn University, Auburn, Alabama, United States of America, 2 Department of Biomedical Engineering, Georgia Institute of Technology and Emory University, Atlanta, Georgia, United States of America, 3 Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, United States of America, 4 Department of Psychology, Emory University, Atlanta, Georgia, United States of America Abstract Background: Brain state classification has been accomplished using features such as voxel intensities, derived from functional magnetic resonance imaging (fMRI) data, as inputs to efficient classifiers such as support vector machines (SVM) and is based on the spatial localization model of brain function. With the advent of the connectionist model of brain function, features from brain networks may provide increased discriminatory power for brain state classification. Methodology/Principal Findings: In this study, we introduce a novel framework where in both functional connectivity (FC) based on instantaneous temporal correlation and effective connectivity (EC) based on causal influence in brain networks are used as features in an SVM classifier. In order to derive those features, we adopt a novel approach recently introduced by us called correlation-purged Granger causa