原创力文档recovering protein-protein and domain-domain interactions from aggregation of ip-ms proteomics of coregulator complexes恢复蛋白质的聚合和domain-domain交互ip-ms coregulator复合物的蛋白质组学.pdfVIP
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recovering protein-protein and domain-domain interactions from aggregation of ip-ms proteomics of coregulator complexes恢复蛋白质的聚合和domain-domain交互ip-ms coregulator复合物的蛋白质组学
Recovering Protein-Protein and Domain-Domain
Interactions from Aggregation of IP-MS Proteomics of
Coregulator Complexes
1 1 1 2 2
Amin R. Mazloom , Ruth Dannenfelser , Neil R. Clark , Arsen V. Grigoryan , Kathryn M. Linder ,
2 1 1 1 3
Timothy J. Cardozo , Julia C. Bond , Aislyn D. W. Boran , Ravi Iyengar , Anna Malovannaya , Rainer B.
3 1
Lanz , Avi Ma’ayan *
1 Department of Pharmacology and Systems Therapeutics, Systems Biology Center New York (SBCNY), Mount Sinai School of Medicine, New York, New York, United States
of America, 2 Department of Pharmacology, New York University School of Medicine, New York, New York, United States of America, 3 Department of Molecular and
Cellular Biology, Baylor College of Medicine, Houston, Texas, United States of America
Abstract
Coregulator proteins (CoRegs) are part of multi-protein complexes that transiently assemble with transcription factors and
chromatin modifiers to regulate gene expression. In this study we analyzed data from 3,290 immuno-precipitations (IP)
followed by mass spectrometry (MS) applied to human cell lines aimed at identifying CoRegs complexes. Using the semi-
quantitative spectral counts, we scored binary protein-protein and domain-domain associations with several equations.
Unlike previous applications, our methods scored prey-prey protein-protein interactions regardless of the baits used. We
also predicted domain-domain interactions underlying predicted protein-protein interactions. The quality of predicted
protein-protein and domain-domain interactions was evaluated using known
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