recruited cells can become transformed and overtake pdgf-induced murine gliomas in vivo during tumor progression招募了细胞可以成为转化和超越pdgf-induced小鼠神经胶质瘤体内肿瘤恶化.pdfVIP

Recruited Cells Can Become Transformed and Overtake PDGF-Induced Murine Gliomas In Vivo during Tumor Progression 1 3 1 1 1 Elena I. Fomchenko , Joseph D. Dougherty , Karim Y. Helmy , Amanda M. Katz , Alexander Pietras , 2,5 1,4 3 1,2,5 Cameron Brennan , Jason T. Huse , Ana Milosevic , Eric C. Holland * 1 Department of Cancer Biology and Genetics, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America, 2 Departments of Surgery (Neurosurgery) and Neurology, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America, 3 Department of Molecular Biology, Rockefeller University, New York, New York, United States of America, 4 Departments of Human Oncology, Pathology and Pathogenesis, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America, 5 Brain Tumor Center, Memorial Sloan Kettering Cancer Center, New York, New York, United States of America Abstract Background: Gliomas are thought to form by clonal expansion from a single cell-of-origin, and progression-associated mutations to occur in its progeny cells. Glioma progression is associated with elevated growth factor signaling and loss of function of tumor suppressors Ink4a, Arf and Pten. Yet, gliomas are cellularly heterogeneous; they recruit and trap normal cells during infiltration. Methodology/Principal Findings: We performed lineage tracing in a retrovirally mediated, molecularly and histologically accurate mouse model of hPDGFb-driven gliomagenesis. We were able to distinguish cells in the tumor that were derived from the cell-of-origin from thos