原创力文档randomised controlled double-blind non-inferiority trial of two antivenoms for saw-scaled or carpet viper (echis ocellatus) envenoming in nigeria随机对照双盲non-inferiority试验两个抗蛇毒血清的锯鳞或地毯蝰(echis ocellatus)下毒在尼日利亚.pdfVIP
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randomised controlled double-blind non-inferiority trial of two antivenoms for saw-scaled or carpet viper (echis ocellatus) envenoming in nigeria随机对照双盲non-inferiority试验两个抗蛇毒血清的锯鳞或地毯蝰(echis ocellatus)下毒在尼日利亚
Randomised Controlled Double-Blind Non-Inferiority
Trial of Two Antivenoms for Saw-Scaled or Carpet Viper
(Echis ocellatus) Envenoming in Nigeria
1 2 3 4 4
Isa S. Abubakar , Saidu B. Abubakar , Abdulrazaq G. Habib *, Abdulsalam Nasidi , Nandul Durfa ,
5 { 6 7 8
Peter O. Yusuf , Solomon Larnyang , John Garnvwa , Elijah Sokomba , Lateef Salako , R. David G.
6 9 9 10
Theakston , Ed Juszczak , Nicola Alder , David A. Warrell , for the Nigeria-UK EchiTab Study Group
1 Department of Community Medicine, Bayero University of Kano, Kano, Nigeria, 2 General Hospital Kaltungo, Kaltungo, Gombe State, Nigeria, 3 Department of Medicine,
Bayero University Kano, Kano, Nigeria, 4 Special Projects Unit, Federal Ministry of Health, Abuja, Nigeria, 5 Faculty of Veterinary Medicine, Ahmadu Bello University, Zaria,
Nigeria, 6 Alistair Reid Venom Research Unit, Liverpool School of Tropical Medicine, Liverpool, United Kingdom, 7 Department of Pharmacology, University of Jos, Jos,
Nigeria, 8 Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan, Nigeria, 9 Centre for Statistics in Medicine, University of Oxford, Oxford, United
Kingdom, 10 Nuffield Department of Clinical Medicine, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom
Abstract
Background: In West Africa, envenoming by saw-scaled or carpet vipers (Echis ocellatus) causes great morbidity and
mortality, but there is a crisis in supply of effective and affordable antivenom (ISRCT.
Methods: In a randomised, double-blind, cont
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