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regulation of early adipose commitment by zfp521早期脂肪zfp521承诺的监管
Regulation of Early Adipose Commitment by Zfp521
Sona Kang1,2, Peter Akerblad1,2,3., Riku Kiviranta4.¤a, Rana K. Gupta2,5¤b, Shingo Kajimura2,5¤c,
1,2 1,2 4 1,2
Michael J. Griffin , Jie Min , Roland Baron , Evan D. Rosen *
1 Division of Endocrinology, Beth Israel Deaconess Medical Center, Boston, Massachusetts, United States of America, 2 Harvard Medical School, Boston, Massachusetts,
¨ ¨
United States of America, 3 AstraZeneca RD Molndal, Molndal, Sweden, 4 Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, and
Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, United States of America, 5 Department of Cancer Biology and Division of Metabolism and
Chronic Disease, Dana-Farber Cancer Institute, Boston, Massachusetts, United States of America
Abstract
While there has been significant progress in determining the transcriptional cascade involved in terminal adipocyte
differentiation, less is known about early events leading to lineage commitment and cell fate choice. It has been recently
discovered that zinc finger protein 423 (Zfp423) is an early actor in adipose determination. Here, we show that a close
paralog of Zfp423, Zfp521, acts as a key regulator of adipose commitment and differentiation in vitro and in vivo. Zfp521
exerts its actions by binding to early B cell factor 1 (Ebf1), a transcription factor required for the generation of adipocyte
progenitors, and inhibiting the expression of Zfp423. Overexpression of Zfp521 in cells greatly inhibits adipogenic potential,
whereas RNAi-mediated knock-down or genetic ablation of Zfp521 enhances
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