原创力文档role of mprf1 and mprf2 in the pathogenicity of enterococcus faecalis角色mprf1和mprf2粪肠球菌的致病性.pdfVIP
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role of mprf1 and mprf2 in the pathogenicity of enterococcus faecalis角色mprf1和mprf2粪肠球菌的致病性
Role of mprF1 and mprF2 in the Pathogenicity of
Enterococcus faecalis
1,2 1 1 1 2
Yinyin Bao , Tuerkan Sakinc , Diana Laverde , Dominique Wobser , Abdellah Benachour ,
1 2 1
Christian Theilacker , Axel Hartke , Johannes Huebner *
´
1 Division of Infectious Diseases, Department of Medicine, University Hospital Freiburg, Freiburg, Germany, 2 EA4655 U2RM Stress/Virulence, Universite de Caen Basse-
Normandie, Caen, France
Abstract
Background: Enterococcus faecalis is one of the leading causes of nosocomial infections. Due to its innate and acquired
resistance to most antibiotics, identification of new targets for antimicrobial treatment of E. faecalis is a high priority. The
multiple peptide resistance factor MprF, which was first described in Staphylococcus aureus, modifies phosphatidylglycerol
with lysin and reduces the negative charge of the membrane, thus increasing resistance to cationic antimicrobial peptides.
We studied the effect of mprF in E. faecalis regarding influence on bacterial physiology and virulence.
Results: Two putative mprF paralogs (mprF1 and mprF2) were identified in E. faecalis by BLAST search using the well-
described S. aureus gene as a lead. Two deletion mutants in E. faecalis 12030 were created by homologous recombination.
Analysis of both mutants by thin-layer chromatography showed that inactivation of mprF2 abolishes the synthesis of three
distinct amino-phosphatidylglycerols (PGs). In contrast, deletion of mprF1 did not interfere with the biosynthesis of amino-
PG. I
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